Detailed information of TA system TA070109

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 379251..379589
• Replicon: chromosome
• Accession: NZ_CP018629
• Organism: Staphylococcus aureus strain MRSA107

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: BTN44_RS01945
• Protein ID: WP_072482930.1
• Coordinates: 379251..379427 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	379415..379589 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTN44_RS01925	377081..377233	+	153	WP_001000059.1	hypothetical protein	-
BTN44_RS01930	377279..377566	+	288	WP_001262621.1	hypothetical protein	-
BTN44_RS01935	377622..377996	+	375	WP_000340977.1	hypothetical protein	-
BTN44_RS01940	378369..379142	+	774	WP_000750412.1	staphylococcal enterotoxin type A	-
BTN44_RS01945	379251..379427	+	177	WP_072482930.1	putative holin-like toxin	Toxin
-	379415..379589	-	175	-	-	Antitoxin
BTN44_RS01955	379639..379893	+	255	WP_000611512.1	phage holin	-
BTN44_RS01960	379905..380660	+	756	WP_000861038.1	CHAP domain-containing protein	-
BTN44_RS01965	380851..381342	+	492	WP_000920041.1	staphylokinase	-
BTN44_RS01980	381994..382329	+	336	Protein_382	SH3 domain-containing protein	-
BTN44_RS01985	382839..383189	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
BTN44_RS01990	383242..383502	-	261	WP_001791826.1	hypothetical protein	-
BTN44_RS02000	383813..383992	-	180	WP_000669789.1	hypothetical protein	-
BTN44_RS02005	384314..384564	-	251	Protein_386	sphingomyelin phosphodiesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sea / sak / scn	338723..383189	44466

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T70109 WP_072482930.1 NZ_CP018629:379251-379427 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T70109 NZ_CP018629:379251-379427 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTCATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT70109 NZ_CP018629:c379589-379415 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATATAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin