Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 755304..755906 Replicon chromosome
Accession NZ_CP018387
Organism Burkholderia pseudomallei strain 2010007509

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BOC45_RS04050 Protein ID WP_085514488.1
Coordinates 755304..755621 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BOC45_RS04055 Protein ID WP_085514489.1
Coordinates 755625..755906 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOC45_RS04030 750794..752011 - 1218 WP_085509438.1 DUF3396 domain-containing protein -
BOC45_RS04035 752036..752794 - 759 WP_085509439.1 VRR-NUC domain-containing protein -
BOC45_RS04040 752791..753315 - 525 WP_085509440.1 PAAR domain-containing protein -
BOC45_RS04045 753903..755273 + 1371 WP_085514487.1 integrase family protein -
BOC45_RS04050 755304..755621 + 318 WP_085514488.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BOC45_RS04055 755625..755906 + 282 WP_085514489.1 helix-turn-helix domain-containing protein Antitoxin
BOC45_RS04060 756007..756375 + 369 WP_009965538.1 hypothetical protein -
BOC45_RS04065 756647..758350 + 1704 Protein_696 hypothetical protein -
BOC45_RS04070 759311..759535 + 225 WP_085514490.1 helix-turn-helix domain-containing protein -
BOC45_RS04075 759536..759898 + 363 WP_157130484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-82)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12131.29 Da        Isoelectric Point: 10.4416

>T69892 WP_085514488.1 NZ_CP018387:755304-755621 [Burkholderia pseudomallei]
MTWHVELIPEAEAELLALPPDMRARFVHIAEMLAEFGPQRVGMPHVRPLEGKLWEIRMTGRDGIARAIYVTRTGQRLVVL
HVFVKKTQKTPRRAIETAYARMKED

Download         Length: 318 bp

>T69892 NZ_CP018387:755304-755621 [Burkholderia pseudomallei]
ATGACGTGGCATGTTGAGTTGATACCCGAGGCCGAAGCCGAATTGCTGGCGCTACCGCCCGATATGCGCGCCCGGTTCGT
CCACATCGCAGAAATGCTGGCGGAGTTCGGACCGCAGCGTGTCGGGATGCCCCATGTGCGCCCACTGGAGGGGAAGCTGT
GGGAAATCCGCATGACGGGCCGGGATGGCATTGCGCGGGCGATATACGTTACGAGGACCGGGCAGCGGCTGGTCGTGCTG
CATGTGTTTGTGAAGAAGACGCAGAAGACCCCGCGCCGTGCCATCGAAACGGCTTACGCCCGGATGAAGGAGGATTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10208.68 Da        Isoelectric Point: 10.2943

>AT69892 WP_085514489.1 NZ_CP018387:755625-755906 [Burkholderia pseudomallei]
MTDLATLKRRLLADPATQAEYEAQAPEFAVARELIAARVRAGLTQEQVAEKMQTTQSTIARMESGRTMPSLRTLSRYAEA
TGSRAVVRLEAAK

Download         Length: 282 bp

>AT69892 NZ_CP018387:755625-755906 [Burkholderia pseudomallei]
ATGACTGACCTTGCAACCCTGAAGAGGCGTCTGCTGGCGGACCCGGCTACCCAGGCCGAGTATGAGGCGCAGGCGCCGGA
ATTTGCCGTCGCGCGTGAACTCATTGCTGCGCGCGTGCGTGCCGGACTGACTCAGGAACAGGTGGCCGAGAAGATGCAGA
CGACCCAATCGACCATCGCACGCATGGAGAGTGGCCGCACGATGCCCTCGCTGCGCACGCTGTCCCGCTACGCCGAAGCG
ACGGGGAGCCGCGCCGTGGTGCGCCTGGAGGCCGCCAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References