Detailed information of TA system TA069886

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 1351392..1352049
• Replicon: chromosome
• Accession: NZ_CP018383
• Organism: Burkholderia pseudomallei strain 2008724758

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: BOC43_RS23675
• Protein ID: WP_009972517.1
• Coordinates: 1351392..1351724 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: BOC43_RS23680
• Protein ID: WP_009972518.1
• Coordinates: 1351732..1352049 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BOC43_RS23650	1347423..1347917	+	495	Protein_1250	terminase	-
BOC43_RS23655	1347914..1348969	+	1056	WP_038785926.1	phage portal protein	-
BOC43_RS23660	1349042..1349326	-	285	WP_004188977.1	hypothetical protein	-
BOC43_RS23665	1349323..1349805	-	483	WP_004200731.1	DUF2778 domain-containing protein	-
BOC43_RS23670	1350125..1351284	+	1160	WP_085955848.1	IS3-like element ISBps2 family transposase	-
BOC43_RS23675	1351392..1351724	+	333	WP_009972517.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BOC43_RS23680	1351732..1352049	+	318	WP_009972518.1	helix-turn-helix domain-containing protein	Antitoxin
BOC43_RS23685	1352248..1353456	+	1209	WP_009972519.1	DUF262 domain-containing protein	-
BOC43_RS39055	1353477..1354139	+	663	WP_133670743.1	hypothetical protein	-
BOC43_RS23695	1354748..1355152	+	405	WP_004200732.1	PaaI family thioesterase	-
BOC43_RS23700	1355190..1356059	+	870	WP_004189208.1	patatin-like phospholipase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (19-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (47-100)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12820.92 Da
• Isoelectric Point: 10.3618

>T69886 WP_009972517.1 NZ_CP018383:1351392-1351724 [Burkholderia pseudomallei]
MKLDWTVIYYNERVKRDVFAFPAGILADYLRLLDLMQEFGADLRMPHSRAMGNGLFELRPKGREGIGRVFYCTHVGQQVV
VLHSFVKKTQETPQRELRIAQARLREVRNG

Nucleotide

• Length: 333 bp

>T69886 NZ_CP018383:1351392-1351724 [Burkholderia pseudomallei]
ATGAAACTTGATTGGACGGTCATCTACTACAACGAACGGGTGAAGCGCGACGTTTTCGCGTTCCCGGCCGGGATTCTTGC
AGACTACCTCCGGCTGTTGGATCTGATGCAAGAGTTCGGTGCGGATCTACGGATGCCGCATTCACGAGCAATGGGTAACG
GGCTGTTTGAACTGCGCCCCAAGGGTAGGGAAGGTATCGGGCGGGTGTTCTATTGCACGCATGTGGGGCAGCAAGTCGTT
GTGCTGCACTCCTTTGTCAAGAAGACGCAGGAAACGCCGCAACGTGAGTTGCGGATCGCCCAAGCACGTTTGAGGGAGGT
GCGTAATGGCTAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11321.89 Da
• Isoelectric Point: 10.2231

>AT69886 WP_009972518.1 NZ_CP018383:1351732-1352049 [Burkholderia pseudomallei]
VKRVRAEGFNPVPHTADDTVRLLAGRNVKTAYDALEDEYTALRAILSARREAGLTQAQIAERMGTTASAVSRLEASLSSE
KHSPSFATLRKYAAACGKKLVISFA

Nucleotide

• Length: 318 bp

>AT69886 NZ_CP018383:1351732-1352049 [Burkholderia pseudomallei]
GTGAAGCGTGTTCGCGCTGAGGGATTCAATCCAGTTCCGCACACAGCGGACGACACGGTGCGTCTGCTCGCCGGTCGCAA
TGTCAAGACGGCGTATGACGCGCTGGAAGACGAATATACGGCGCTGCGCGCGATTCTGTCTGCTCGTCGGGAAGCGGGTC
TGACGCAGGCGCAAATAGCCGAACGTATGGGCACAACCGCGTCAGCGGTTTCAAGGCTTGAGGCATCTTTGTCGAGTGAA
AAGCATTCGCCGTCGTTCGCGACTCTCCGTAAATATGCGGCCGCGTGCGGCAAAAAGCTCGTAATTTCATTTGCTTAG