69655

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2960584..2961232 Replicon chromosome
Accession NZ_CP018305
Organism Mycobacterium tuberculosis strain M0018684-2

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag BOM22_RS14455 Protein ID WP_003899414.1
Coordinates 2960584..2960907 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag BOM22_RS14460 Protein ID WP_003899415.1
Coordinates 2960987..2961232 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOM22_RS14425 2955907..2956905 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
BOM22_RS14430 2956919..2957383 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
BOM22_RS14435 2957371..2957622 + 252 WP_003908028.1 hypothetical protein -
BOM22_RS14440 2957793..2959232 - 1440 WP_003899411.1 phage major capsid protein -
BOM22_RS14445 2959240..2959773 - 534 WP_003899412.1 HK97 family phage prohead protease -
BOM22_RS14450 2959926..2960417 - 492 WP_003900541.1 phage terminase small subunit P27 family -
BOM22_RS14455 2960584..2960907 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
BOM22_RS14460 2960987..2961232 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
BOM22_RS14465 2961229..2962656 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
BOM22_RS14470 2962658..2963050 - 393 WP_003899417.1 DUF2742 domain-containing protein -
BOM22_RS14475 2963047..2963307 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
BOM22_RS14480 2963324..2963686 - 363 WP_003900543.1 hypothetical protein -
BOM22_RS14485 2963689..2964816 - 1128 WP_003899420.1 site-specific integrase -
BOM22_RS14490 2964961..2965188 - 228 WP_003899421.1 hypothetical protein -
BOM22_RS14495 2965185..2965574 - 390 WP_003899422.1 hypothetical protein -
BOM22_RS14500 2965480..2965752 + 273 WP_003900544.1 hypothetical protein -
BOM22_RS14505 2965851..2966084 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2955907..2964816 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T69655 WP_003899414.1 NZ_CP018305:c2960907-2960584 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T69655 NZ_CP018305:c2960907-2960584 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT69655 WP_003899415.1 NZ_CP018305:c2961232-2960987 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT69655 NZ_CP018305:c2961232-2960987 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References