Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2964110..2964758 Replicon chromosome
Accession NZ_CP018304
Organism Mycobacterium tuberculosis strain M0002959-6

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag BOK72_RS14475 Protein ID WP_052635321.1
Coordinates 2964110..2964433 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag BOK72_RS14480 Protein ID WP_003899415.1
Coordinates 2964513..2964758 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOK72_RS14445 2959433..2960431 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
BOK72_RS14450 2960445..2960909 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
BOK72_RS14455 2960897..2961148 + 252 WP_003908028.1 hypothetical protein -
BOK72_RS14460 2961319..2962758 - 1440 WP_003899411.1 phage major capsid protein -
BOK72_RS14465 2962766..2963299 - 534 WP_003899412.1 HK97 family phage prohead protease -
BOK72_RS14470 2963452..2963943 - 492 WP_003900541.1 phage terminase small subunit P27 family -
BOK72_RS14475 2964110..2964433 - 324 WP_052635321.1 type II toxin-antitoxin system toxin Toxin
BOK72_RS14480 2964513..2964758 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
BOK72_RS14485 2964755..2966182 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
BOK72_RS14490 2966184..2966576 - 393 WP_003899417.1 DUF2742 domain-containing protein -
BOK72_RS14495 2966573..2966833 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
BOK72_RS14500 2966850..2967212 - 363 WP_003900543.1 hypothetical protein -
BOK72_RS14505 2967215..2968342 - 1128 WP_003899420.1 site-specific integrase -
BOK72_RS14510 2968487..2968714 - 228 WP_003899421.1 hypothetical protein -
BOK72_RS14515 2968711..2969100 - 390 WP_003899422.1 hypothetical protein -
BOK72_RS14520 2969006..2969278 + 273 WP_003900544.1 hypothetical protein -
BOK72_RS14525 2969377..2969610 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2959433..2968342 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12328.80 Da        Isoelectric Point: 8.6717

>T69594 WP_052635321.1 NZ_CP018304:c2964433-2964110 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRPHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T69594 NZ_CP018304:c2964433-2964110 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCC
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT69594 WP_003899415.1 NZ_CP018304:c2964758-2964513 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT69594 NZ_CP018304:c2964758-2964513 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References