Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2959827..2960475 Replicon chromosome
Accession NZ_CP018303
Organism Mycobacterium tuberculosis strain I0004241-1

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag BOJ25_RS14455 Protein ID WP_052635321.1
Coordinates 2959827..2960150 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag BOJ25_RS14460 Protein ID WP_003899415.1
Coordinates 2960230..2960475 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOJ25_RS14425 2955150..2956148 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
BOJ25_RS14430 2956162..2956626 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
BOJ25_RS14435 2956614..2956865 + 252 WP_003908028.1 hypothetical protein -
BOJ25_RS14440 2957036..2958475 - 1440 WP_003899411.1 phage major capsid protein -
BOJ25_RS14445 2958483..2959016 - 534 WP_003899412.1 HK97 family phage prohead protease -
BOJ25_RS14450 2959169..2959660 - 492 WP_003900541.1 phage terminase small subunit P27 family -
BOJ25_RS14455 2959827..2960150 - 324 WP_052635321.1 type II toxin-antitoxin system toxin Toxin
BOJ25_RS14460 2960230..2960475 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
BOJ25_RS14465 2960472..2961899 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
BOJ25_RS14470 2961901..2962293 - 393 WP_003899417.1 DUF2742 domain-containing protein -
BOJ25_RS14475 2962290..2962550 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
BOJ25_RS14480 2962567..2962929 - 363 WP_003900543.1 hypothetical protein -
BOJ25_RS14485 2962932..2964059 - 1128 WP_003899420.1 site-specific integrase -
BOJ25_RS14490 2964204..2964431 - 228 WP_003899421.1 hypothetical protein -
BOJ25_RS14495 2964428..2964817 - 390 WP_003899422.1 hypothetical protein -
BOJ25_RS14500 2964723..2964995 + 273 WP_003900544.1 hypothetical protein -
BOJ25_RS14505 2965094..2965327 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2955150..2964059 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12328.80 Da        Isoelectric Point: 8.6717

>T69533 WP_052635321.1 NZ_CP018303:c2960150-2959827 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRPHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T69533 NZ_CP018303:c2960150-2959827 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCC
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT69533 WP_003899415.1 NZ_CP018303:c2960475-2960230 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT69533 NZ_CP018303:c2960475-2960230 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References