Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2956775..2957423 Replicon chromosome
Accession NZ_CP018301
Organism Mycobacterium tuberculosis strain I0002801-4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag BOJ61_RS14415 Protein ID WP_003899414.1
Coordinates 2956775..2957098 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag BOJ61_RS14420 Protein ID WP_003899415.1
Coordinates 2957178..2957423 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOJ61_RS14385 2952098..2953096 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
BOJ61_RS14390 2953110..2953574 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
BOJ61_RS14395 2953562..2953813 + 252 WP_003908028.1 hypothetical protein -
BOJ61_RS14400 2953984..2955423 - 1440 WP_003899411.1 phage major capsid protein -
BOJ61_RS14405 2955431..2955964 - 534 WP_003899412.1 HK97 family phage prohead protease -
BOJ61_RS14410 2956117..2956608 - 492 WP_003900541.1 phage terminase small subunit P27 family -
BOJ61_RS14415 2956775..2957098 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
BOJ61_RS14420 2957178..2957423 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
BOJ61_RS14425 2957420..2958847 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
BOJ61_RS14430 2958849..2959241 - 393 WP_003899417.1 DUF2742 domain-containing protein -
BOJ61_RS14435 2959238..2959498 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
BOJ61_RS14440 2959515..2959877 - 363 WP_003900543.1 hypothetical protein -
BOJ61_RS14445 2959880..2961007 - 1128 WP_003899420.1 site-specific integrase -
BOJ61_RS14450 2961152..2961379 - 228 WP_003899421.1 hypothetical protein -
BOJ61_RS14455 2961376..2961765 - 390 WP_003899422.1 hypothetical protein -
BOJ61_RS14460 2961671..2961943 + 273 WP_003900544.1 hypothetical protein -
BOJ61_RS14465 2962042..2962275 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2952098..2961007 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T69412 WP_003899414.1 NZ_CP018301:c2957098-2956775 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T69412 NZ_CP018301:c2957098-2956775 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT69412 WP_003899415.1 NZ_CP018301:c2957423-2957178 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT69412 NZ_CP018301:c2957423-2957178 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References