69351

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2960748..2961396 Replicon chromosome
Accession NZ_CP018300
Organism Mycobacterium tuberculosis strain I0002353-6

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag BOM19_RS14460 Protein ID WP_003899414.1
Coordinates 2960748..2961071 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag BOM19_RS14465 Protein ID WP_003899415.1
Coordinates 2961151..2961396 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOM19_RS14430 2956071..2957069 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
BOM19_RS14435 2957083..2957547 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
BOM19_RS14440 2957535..2957786 + 252 WP_003908028.1 hypothetical protein -
BOM19_RS14445 2957957..2959396 - 1440 WP_003899411.1 phage major capsid protein -
BOM19_RS14450 2959404..2959937 - 534 WP_003899412.1 HK97 family phage prohead protease -
BOM19_RS14455 2960090..2960581 - 492 WP_003900541.1 phage terminase small subunit P27 family -
BOM19_RS14460 2960748..2961071 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
BOM19_RS14465 2961151..2961396 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
BOM19_RS14470 2961393..2962820 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
BOM19_RS14475 2962822..2963214 - 393 WP_003899417.1 DUF2742 domain-containing protein -
BOM19_RS14480 2963211..2963471 - 261 WP_014585547.1 helix-turn-helix domain-containing protein -
BOM19_RS14485 2963488..2963850 - 363 WP_003900543.1 hypothetical protein -
BOM19_RS14490 2963853..2964980 - 1128 WP_003899420.1 site-specific integrase -
BOM19_RS14495 2965125..2965352 - 228 WP_003899421.1 hypothetical protein -
BOM19_RS14500 2965349..2965738 - 390 WP_003899422.1 hypothetical protein -
BOM19_RS14505 2965644..2965916 + 273 WP_003900544.1 hypothetical protein -
BOM19_RS14510 2966015..2966248 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2956071..2964980 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T69351 WP_003899414.1 NZ_CP018300:c2961071-2960748 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T69351 NZ_CP018300:c2961071-2960748 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT69351 WP_003899415.1 NZ_CP018300:c2961396-2961151 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT69351 NZ_CP018300:c2961396-2961151 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References