Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1957973..1958558 Replicon chromosome
Accession NZ_CP018260
Organism Acinetobacter haemolyticus strain XH900

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BSR56_RS09565 Protein ID WP_100833777.1
Coordinates 1957973..1958293 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BSR56_RS09570 Protein ID WP_005082538.1
Coordinates 1958286..1958558 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSR56_RS09540 1953392..1953637 - 246 WP_100833773.1 hypothetical protein -
BSR56_RS09545 1953772..1954278 - 507 WP_100833774.1 ureidoglycolate lyase -
BSR56_RS09550 1954571..1955575 - 1005 WP_100833775.1 allantoicase -
BSR56_RS09555 1955742..1956452 + 711 WP_075315409.1 FadR family transcriptional regulator -
BSR56_RS09560 1956632..1957789 + 1158 WP_100833776.1 FAD-dependent urate hydroxylase HpxO -
BSR56_RS09565 1957973..1958293 + 321 WP_100833777.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BSR56_RS09570 1958286..1958558 + 273 WP_005082538.1 helix-turn-helix domain-containing protein Antitoxin
BSR56_RS09575 1958813..1960108 - 1296 WP_100833778.1 OprD family outer membrane porin -
BSR56_RS09580 1960292..1961668 - 1377 WP_100833779.1 purine permease -
BSR56_RS09585 1961716..1962051 - 336 WP_100833780.1 hydroxyisourate hydrolase -
BSR56_RS09590 1962051..1962551 - 501 WP_100833781.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(17-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12154.04 Da        Isoelectric Point: 5.8827

>T69300 WP_100833777.1 NZ_CP018260:1957973-1958293 [Acinetobacter haemolyticus]
MLFIETSIFTKQIKELISDDEYRELQQELLVQPDKGDLIKNGGGIRKVRCAQGSKGKSGGIRVIYYWITEDDQIFMLLAY
PKSVKENLTDKETAILCQLVKEQFHG

Download         Length: 321 bp

>T69300 NZ_CP018260:1957973-1958293 [Acinetobacter haemolyticus]
ATGCTATTTATTGAAACCAGTATTTTTACCAAACAAATCAAAGAGCTTATCTCTGATGATGAATATAGAGAACTCCAACA
AGAACTTTTAGTTCAGCCAGATAAGGGAGATCTCATTAAAAATGGTGGTGGAATTCGTAAAGTACGTTGTGCCCAAGGCA
GTAAAGGAAAAAGTGGTGGCATTCGAGTAATTTATTACTGGATCACTGAAGATGATCAGATATTTATGCTATTGGCTTAC
CCTAAATCTGTTAAAGAAAACCTAACTGATAAAGAGACCGCTATCCTATGTCAACTTGTGAAGGAGCAATTTCATGGATA
A

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10094.53 Da        Isoelectric Point: 8.6797

>AT69300 WP_005082538.1 NZ_CP018260:1958286-1958558 [Acinetobacter haemolyticus]
MDNNLFDDLVASIKEAGAIKRNEVKASRVTELTLPDIKEVREKTGLSQTEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Download         Length: 273 bp

>AT69300 NZ_CP018260:1958286-1958558 [Acinetobacter haemolyticus]
ATGGATAATAACTTATTTGATGACCTCGTTGCTTCGATCAAAGAAGCAGGAGCTATTAAACGTAATGAAGTTAAAGCAAG
TCGAGTGACTGAGCTGACTCTTCCTGATATTAAAGAAGTTCGTGAGAAAACAGGATTGAGCCAAACAGAATTTGCTGCAC
GTTTGCATATTAGCCCTCGTACACTTCAGAACTGGGAACAAGGCAGACGCTATCCAACAGGGCCAGCAGCAACCCTGATT
CGCATTCTAGATGCACATCCGAGCCTGATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References