Detailed information of TA system TA069278

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-ohsC/Ldr(toxin)
• Location: 4480794..4481015
• Replicon: chromosome
• Accession: NZ_CP018252
• Organism: Escherichia coli strain 9000

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: BFL16_RS24960
• Protein ID: WP_001295224.1
• Coordinates: 4480794..4480901 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	4480950..4481015 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BFL16_RS24935	4476047..4476799	-	753	Protein_4418	cellulose biosynthesis protein BcsQ	-
BFL16_RS24940	4476811..4476999	-	189	WP_001063316.1	YhjR family protein	-
BFL16_RS24945	4477272..4478843	+	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
BFL16_RS24950	4478840..4479031	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
BFL16_RS24955	4479028..4480707	+	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
BFL16_RS24960	4480794..4480901	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4480950..4481015	+	66	NuclAT_16	-	Antitoxin
-	4480950..4481015	+	66	NuclAT_16	-	Antitoxin
-	4480950..4481015	+	66	NuclAT_16	-	Antitoxin
-	4480950..4481015	+	66	NuclAT_16	-	Antitoxin
-	4480950..4481015	+	66	NuclAT_21	-	Antitoxin
-	4480950..4481015	+	66	NuclAT_21	-	Antitoxin
-	4480950..4481015	+	66	NuclAT_21	-	Antitoxin
-	4480950..4481015	+	66	NuclAT_21	-	Antitoxin
BFL16_RS24975	4481377..4482648	+	1272	WP_001301684.1	amino acid permease	-
BFL16_RS24980	4482678..4483682	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
BFL16_RS24985	4483679..4484662	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
BFL16_RS24990	4484673..4485575	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T69278 WP_001295224.1 NZ_CP018252:c4480901-4480794 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T69278 NZ_CP018252:c4480901-4480794 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT69278 NZ_CP018252:4480950-4481015 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin