Detailed information of TA system TA069260

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2115709..2115934
• Replicon: chromosome
• Accession: NZ_CP018252
• Organism: Escherichia coli strain 9000

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: BFL16_RS11645
• Protein ID: WP_000935259.1
• Coordinates: 2115709..2115921 (-)
• Length: 71 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2115876..2115934 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BFL16_RS11595	2110712..2111143	-	432	WP_001302123.1	tellurite resistance protein	-
BFL16_RS11610	2111594..2112307	-	714	WP_000301797.1	helix-turn-helix domain-containing protein	-
BFL16_RS31835	2112443..2112640	-	198	WP_000917763.1	hypothetical protein	-
BFL16_RS11620	2112865..2113419	-	555	WP_000640035.1	DUF1133 family protein	-
BFL16_RS11625	2113482..2113787	-	306	WP_001217444.1	RusA family crossover junction endodeoxyribonuclease	-
BFL16_RS11630	2113800..2114849	-	1050	WP_001265229.1	DUF968 domain-containing protein	-
BFL16_RS11635	2114851..2115123	-	273	WP_000191872.1	hypothetical protein	-
BFL16_RS11640	2115245..2115589	-	345	WP_000756596.1	YgiW/YdeI family stress tolerance OB fold protein	-
BFL16_RS11645	2115709..2115921	-	213	WP_000935259.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	2115876..2115934	+	59	-	-	Antitoxin
BFL16_RS11650	2116155..2116712	-	558	WP_000104474.1	DUF551 domain-containing protein	-
BFL16_RS11655	2116714..2116932	-	219	WP_000683609.1	DUF4014 family protein	-
BFL16_RS11660	2117060..2117371	-	312	WP_001289673.1	hypothetical protein	-
BFL16_RS11665	2117364..2117591	-	228	WP_000699809.1	hypothetical protein	-
BFL16_RS11670	2117588..2117869	-	282	WP_000603384.1	DNA-binding protein	-
BFL16_RS11675	2117902..2118618	-	717	WP_000450627.1	DUF1627 domain-containing protein	-
BFL16_RS31840	2118652..2119113	-	462	WP_000139447.1	replication protein	-
BFL16_RS31845	2119106..2120149	-	1044	WP_001262402.1	hypothetical protein	-
BFL16_RS11690	2120218..2120643	-	426	WP_000693878.1	Rha family transcriptional regulator	-
BFL16_RS11695	2120627..2120869	-	243	WP_000747948.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	nleC / nleG7' / paa	2031243..2177609	146366

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 71 a.a.
• Molecular weight: 7887.47 Da
• Isoelectric Point: 9.2654

>T69260 WP_000935259.1 NZ_CP018252:c2115921-2115709 [Escherichia coli]
MLNTCRLASYVPKGKEKQAMKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK

Nucleotide

• Length: 213 bp

>T69260 NZ_CP018252:c2115921-2115709 [Escherichia coli]
ATGCTGAACACATGTAGGTTAGCCTCTTACGTGCCGAAAGGCAAGGAGAAGCAGGCTATGAAGCAGCAAAAGGCGATGTT
AATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAAAGACCTCTGCGAGGTGCGAATCC
GAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT69260 NZ_CP018252:2115876-2115934 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Antitoxin