Detailed information of TA system TA069256

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 1651282..1651496
• Replicon: chromosome
• Accession: NZ_CP018252
• Organism: Escherichia coli strain 9000

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: J7R083
• Locus tag: BFL16_RS09010
• Protein ID: WP_000170963.1
• Coordinates: 1651282..1651389 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	1651437..1651496 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BFL16_RS08975	1646591..1647673	+	1083	WP_000804726.1	peptide chain release factor 1	-
BFL16_RS08980	1647673..1648506	+	834	WP_000456466.1	peptide chain release factor N(5)-glutamine methyltransferase	-
BFL16_RS08985	1648503..1648895	+	393	WP_000200380.1	invasion regulator SirB2	-
BFL16_RS08990	1648899..1649708	+	810	WP_001257044.1	invasion regulator SirB1	-
BFL16_RS08995	1649744..1650598	+	855	WP_000811067.1	3-deoxy-8-phosphooctulonate synthase	-
BFL16_RS09000	1650746..1650853	-	108	WP_000170954.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	1650906..1650967	+	62	NuclAT_24	-	-
-	1650906..1650967	+	62	NuclAT_24	-	-
-	1650906..1650967	+	62	NuclAT_24	-	-
-	1650906..1650967	+	62	NuclAT_24	-	-
-	1650906..1650967	+	62	NuclAT_26	-	-
-	1650906..1650967	+	62	NuclAT_26	-	-
-	1650906..1650967	+	62	NuclAT_26	-	-
-	1650906..1650967	+	62	NuclAT_26	-	-
-	1650906..1650967	+	62	NuclAT_28	-	-
-	1650906..1650967	+	62	NuclAT_28	-	-
-	1650906..1650967	+	62	NuclAT_28	-	-
-	1650906..1650967	+	62	NuclAT_28	-	-
-	1650906..1650967	+	62	NuclAT_30	-	-
-	1650906..1650967	+	62	NuclAT_30	-	-
-	1650906..1650967	+	62	NuclAT_30	-	-
-	1650906..1650967	+	62	NuclAT_30	-	-
-	1650906..1650967	+	62	NuclAT_32	-	-
-	1650906..1650967	+	62	NuclAT_32	-	-
-	1650906..1650967	+	62	NuclAT_32	-	-
-	1650906..1650967	+	62	NuclAT_32	-	-
-	1650906..1650968	+	63	NuclAT_17	-	-
-	1650906..1650968	+	63	NuclAT_17	-	-
-	1650906..1650968	+	63	NuclAT_17	-	-
-	1650906..1650968	+	63	NuclAT_17	-	-
-	1650906..1650968	+	63	NuclAT_18	-	-
-	1650906..1650968	+	63	NuclAT_18	-	-
-	1650906..1650968	+	63	NuclAT_18	-	-
-	1650906..1650968	+	63	NuclAT_18	-	-
-	1650906..1650968	+	63	NuclAT_19	-	-
-	1650906..1650968	+	63	NuclAT_19	-	-
-	1650906..1650968	+	63	NuclAT_19	-	-
-	1650906..1650968	+	63	NuclAT_19	-	-
-	1650906..1650968	+	63	NuclAT_20	-	-
-	1650906..1650968	+	63	NuclAT_20	-	-
-	1650906..1650968	+	63	NuclAT_20	-	-
-	1650906..1650968	+	63	NuclAT_20	-	-
-	1650906..1650968	+	63	NuclAT_22	-	-
-	1650906..1650968	+	63	NuclAT_22	-	-
-	1650906..1650968	+	63	NuclAT_22	-	-
-	1650906..1650968	+	63	NuclAT_22	-	-
-	1650906..1650968	+	63	NuclAT_23	-	-
-	1650906..1650968	+	63	NuclAT_23	-	-
-	1650906..1650968	+	63	NuclAT_23	-	-
-	1650906..1650968	+	63	NuclAT_23	-	-
BFL16_RS09010	1651282..1651389	-	108	WP_000170963.1	small toxic polypeptide LdrB	Toxin
-	1651437..1651496	+	60	NuclAT_25	-	Antitoxin
-	1651437..1651496	+	60	NuclAT_25	-	Antitoxin
-	1651437..1651496	+	60	NuclAT_25	-	Antitoxin
-	1651437..1651496	+	60	NuclAT_25	-	Antitoxin
-	1651437..1651496	+	60	NuclAT_27	-	Antitoxin
-	1651437..1651496	+	60	NuclAT_27	-	Antitoxin
-	1651437..1651496	+	60	NuclAT_27	-	Antitoxin
-	1651437..1651496	+	60	NuclAT_27	-	Antitoxin
-	1651437..1651496	+	60	NuclAT_29	-	Antitoxin
-	1651437..1651496	+	60	NuclAT_29	-	Antitoxin
-	1651437..1651496	+	60	NuclAT_29	-	Antitoxin
-	1651437..1651496	+	60	NuclAT_29	-	Antitoxin
-	1651437..1651496	+	60	NuclAT_31	-	Antitoxin
-	1651437..1651496	+	60	NuclAT_31	-	Antitoxin
-	1651437..1651496	+	60	NuclAT_31	-	Antitoxin
-	1651437..1651496	+	60	NuclAT_31	-	Antitoxin
-	1651437..1651496	+	60	NuclAT_33	-	Antitoxin
-	1651437..1651496	+	60	NuclAT_33	-	Antitoxin
-	1651437..1651496	+	60	NuclAT_33	-	Antitoxin
-	1651437..1651496	+	60	NuclAT_33	-	Antitoxin
BFL16_RS09015	1651788..1652888	-	1101	WP_001301956.1	sodium-potassium/proton antiporter ChaA	-
BFL16_RS09020	1653158..1653388	+	231	WP_001146444.1	putative cation transport regulator ChaB	-
BFL16_RS09025	1653549..1654244	+	696	WP_001301489.1	glutathione-specific gamma-glutamylcyclotransferase	-
BFL16_RS09030	1654288..1654641	-	354	WP_001169669.1	DsrE/F sulfur relay family protein YchN	-
BFL16_RS09035	1654827..1656221	+	1395	WP_000086192.1	inverse autotransporter invasin YchO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3971.74 Da
• Isoelectric Point: 11.4779

>T69256 WP_000170963.1 NZ_CP018252:c1651389-1651282 [Escherichia coli]
MTLAQFAMTFWHDLAAPILAGIITAAIVGWWRNRK

Nucleotide

• Length: 108 bp

>T69256 NZ_CP018252:c1651389-1651282 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 60 bp

>AT69256 NZ_CP018252:1651437-1651496 [Escherichia coli]
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Antitoxin