Detailed information of TA system TA069253

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1188878..1189103
• Replicon: chromosome
• Accession: NZ_CP018252
• Organism: Escherichia coli strain 9000

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: BFL16_RS06075
• Protein ID: WP_000813263.1
• Coordinates: 1188948..1189103 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1188878..1188936 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BFL16_RS06050	1184153..1185244	+	1092	WP_001205823.1	hypothetical protein	-
BFL16_RS06055	1185251..1185997	+	747	WP_000788751.1	ATP-binding protein	-
BFL16_RS06060	1186019..1186789	+	771	WP_000450992.1	DUF1627 domain-containing protein	-
BFL16_RS06065	1186805..1187218	+	414	WP_001151233.1	DUF977 family protein	-
BFL16_RS06070	1187570..1188343	-	774	WP_000160654.1	alpha/beta hydrolase	-
BFL16_RS31605	1188709..1188846	-	138	WP_000955173.1	hypothetical protein	-
-	1188878..1188936	-	59	-	-	Antitoxin
BFL16_RS06075	1188948..1189103	+	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
BFL16_RS06080	1189271..1189549	+	279	WP_001341388.1	hypothetical protein	-
BFL16_RS06085	1189551..1190600	+	1050	WP_001265172.1	DUF968 domain-containing protein	-
BFL16_RS06090	1190613..1190984	+	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
BFL16_RS06095	1190974..1191345	+	372	WP_000090264.1	antitermination protein	-
BFL16_RS06100	1191497..1192315	+	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
BFL16_RS06105	1192602..1192798	+	197	Protein_1086	TrmB family transcriptional regulator	-
BFL16_RS06110	1192936..1193649	+	714	WP_000261909.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T69253 WP_000813263.1 NZ_CP018252:1188948-1189103 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T69253 NZ_CP018252:1188948-1189103 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT69253 NZ_CP018252:c1188936-1188878 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin