Detailed information of TA system TA069237

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-ohsC/Ldr(toxin)
• Location: 4410637..4410858
• Replicon: chromosome
• Accession: NZ_CP018250
• Organism: Escherichia coli strain 10671

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: BFL17_RS24275
• Protein ID: WP_001295224.1
• Coordinates: 4410637..4410744 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	4410793..4410858 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BFL17_RS24250	4405890..4406642	-	753	Protein_4316	cellulose biosynthesis protein BcsQ	-
BFL17_RS24255	4406654..4406842	-	189	WP_001063316.1	YhjR family protein	-
BFL17_RS24260	4407115..4408686	+	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
BFL17_RS24265	4408683..4408874	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
BFL17_RS24270	4408871..4410550	+	1680	WP_072608506.1	cellulose biosynthesis protein BcsG	-
BFL17_RS24275	4410637..4410744	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4410793..4410858	+	66	NuclAT_16	-	Antitoxin
-	4410793..4410858	+	66	NuclAT_16	-	Antitoxin
-	4410793..4410858	+	66	NuclAT_16	-	Antitoxin
-	4410793..4410858	+	66	NuclAT_16	-	Antitoxin
-	4410793..4410858	+	66	NuclAT_21	-	Antitoxin
-	4410793..4410858	+	66	NuclAT_21	-	Antitoxin
-	4410793..4410858	+	66	NuclAT_21	-	Antitoxin
-	4410793..4410858	+	66	NuclAT_21	-	Antitoxin
BFL17_RS24290	4411220..4412491	+	1272	WP_001301684.1	amino acid permease	-
BFL17_RS24295	4412521..4413525	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
BFL17_RS24300	4413522..4414505	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
BFL17_RS24305	4414516..4415418	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T69237 WP_001295224.1 NZ_CP018250:c4410744-4410637 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T69237 NZ_CP018250:c4410744-4410637 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT69237 NZ_CP018250:4410793-4410858 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin