Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2069679..2070150 Replicon chromosome
Accession NZ_CP018250
Organism Escherichia coli strain 10671

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag BFL17_RS11260 Protein ID WP_001303511.1
Coordinates 2069872..2070150 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag BFL17_RS11255 Protein ID WP_001302048.1
Coordinates 2069679..2069870 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFL17_RS11210 2064887..2065471 - 585 WP_000206793.1 DUF551 domain-containing protein -
BFL17_RS11215 2065528..2065923 - 396 WP_001118159.1 DUF977 family protein -
BFL17_RS11220 2065939..2066708 - 770 Protein_1987 DUF1627 domain-containing protein -
BFL17_RS11230 2066734..2067474 - 741 WP_000788938.1 ATP-binding protein -
BFL17_RS11235 2067481..2068443 - 963 WP_000095669.1 helix-turn-helix domain-containing protein -
BFL17_RS11240 2068466..2068890 - 425 Protein_1990 Rha family transcriptional regulator -
BFL17_RS11245 2068887..2069189 - 303 WP_000172738.1 transcriptional regulator -
BFL17_RS11250 2069287..2069658 + 372 WP_001169686.1 hypothetical protein -
BFL17_RS11255 2069679..2069870 + 192 WP_001302048.1 hypothetical protein Antitoxin
BFL17_RS11260 2069872..2070150 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BFL17_RS11270 2070503..2070802 + 300 WP_001240334.1 hypothetical protein -
BFL17_RS11275 2070874..2071092 + 219 WP_001171930.1 hypothetical protein -
BFL17_RS11285 2071661..2071849 + 189 WP_000449192.1 cell division inhibition protein DicB -
BFL17_RS11290 2071846..2072037 + 192 WP_001090200.1 DUF1482 family protein -
BFL17_RS11295 2072130..2074601 + 2472 WP_000048458.1 exonuclease -
BFL17_RS11300 2074674..2074925 + 252 WP_000005552.1 excisionase family protein -
BFL17_RS31030 2074960..2075144 + 185 Protein_2001 DUF3596 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - nleA/espI 2028452..2077311 48859


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T69220 WP_001303511.1 NZ_CP018250:2069872-2070150 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T69220 NZ_CP018250:2069872-2070150 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT69220 WP_001302048.1 NZ_CP018250:2069679-2069870 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT69220 NZ_CP018250:2069679-2069870 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References