69203

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 5309550..5309962 Replicon chromosome
Accession NZ_CP018247
Organism Escherichia coli strain 7784

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag BFL18_RS28905 Protein ID WP_000132630.1
Coordinates 5309550..5309891 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 5309886..5309962 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFL18_RS31485 5305118..5305318 + 201 WP_001310455.1 hypothetical protein -
BFL18_RS28880 5305561..5306973 - 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
BFL18_RS28890 5307150..5307314 + 165 WP_000394274.1 DUF1127 domain-containing protein -
BFL18_RS28895 5307411..5308292 + 882 WP_001304007.1 DUF262 domain-containing protein -
BFL18_RS28900 5308340..5309503 + 1164 WP_001304006.1 DUF1524 domain-containing protein -
BFL18_RS28905 5309550..5309891 - 342 WP_000132630.1 endoribonuclease SymE Toxin
- 5309886..5309962 + 77 NuclAT_14 - Antitoxin
- 5309886..5309962 + 77 NuclAT_14 - Antitoxin
- 5309886..5309962 + 77 NuclAT_14 - Antitoxin
- 5309886..5309962 + 77 NuclAT_14 - Antitoxin
- 5309886..5309962 + 77 NuclAT_15 - Antitoxin
- 5309886..5309962 + 77 NuclAT_15 - Antitoxin
- 5309886..5309962 + 77 NuclAT_15 - Antitoxin
- 5309886..5309962 + 77 NuclAT_15 - Antitoxin
BFL18_RS28910 5310112..5311866 - 1755 WP_000110082.1 restriction endonuclease subunit S -
BFL18_RS28915 5311866..5313335 - 1470 WP_001302468.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 5299043..5317763 18720


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T69203 WP_000132630.1 NZ_CP018247:c5309891-5309550 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T69203 NZ_CP018247:c5309891-5309550 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT69203 NZ_CP018247:5309886-5309962 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References