Detailed information of TA system TA069181

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2092087..2092312
• Replicon: chromosome
• Accession: NZ_CP018247
• Organism: Escherichia coli strain 7784

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: A0A1Q4PF16
• Locus tag: BFL18_RS11465
• Protein ID: WP_000813258.1
• Coordinates: 2092087..2092242 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2092254..2092312 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BFL18_RS11415	2087090..2087521	-	432	WP_001302123.1	tellurite resistance protein	-
BFL18_RS11430	2087972..2088685	-	714	WP_000301797.1	helix-turn-helix domain-containing protein	-
BFL18_RS30775	2088821..2089018	-	198	WP_000917763.1	hypothetical protein	-
BFL18_RS11440	2089243..2089797	-	555	WP_000640035.1	DUF1133 family protein	-
BFL18_RS11445	2089860..2090165	-	306	WP_001217444.1	RusA family crossover junction endodeoxyribonuclease	-
BFL18_RS11450	2090178..2091227	-	1050	WP_001265229.1	DUF968 domain-containing protein	-
BFL18_RS11455	2091229..2091501	-	273	WP_000191872.1	hypothetical protein	-
BFL18_RS11460	2091623..2091967	-	345	WP_000756596.1	YgiW/YdeI family stress tolerance OB fold protein	-
BFL18_RS11465	2092087..2092242	-	156	WP_000813258.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	2092254..2092312	+	59	-	-	Antitoxin
BFL18_RS11470	2092533..2093090	-	558	WP_000104474.1	DUF551 domain-containing protein	-
BFL18_RS11475	2093092..2093310	-	219	WP_000683609.1	DUF4014 family protein	-
BFL18_RS11480	2093438..2093749	-	312	WP_001289673.1	hypothetical protein	-
BFL18_RS11485	2093742..2093969	-	228	WP_000699809.1	hypothetical protein	-
BFL18_RS11490	2093966..2094247	-	282	WP_000603384.1	DNA-binding protein	-
BFL18_RS11495	2094280..2094955	-	676	Protein_2035	DUF1627 domain-containing protein	-
BFL18_RS30780	2094989..2095450	-	462	WP_000139447.1	replication protein	-
BFL18_RS30785	2095443..2096486	-	1044	WP_001262402.1	hypothetical protein	-
BFL18_RS11510	2096555..2096980	-	426	WP_000693878.1	Rha family transcriptional regulator	-
BFL18_RS11515	2096964..2097206	-	243	WP_000747948.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2054972..2113145	58173

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5767.95 Da
• Isoelectric Point: 7.7942

>T69181 WP_000813258.1 NZ_CP018247:c2092242-2092087 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK

Nucleotide

• Length: 156 bp

>T69181 NZ_CP018247:c2092242-2092087 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT69181 NZ_CP018247:2092254-2092312 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A1Q4PF16

Antitoxin