Detailed information of TA system TA069163

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-agrB/Ldr(toxin)
• Location: 4485132..4485353
• Replicon: chromosome
• Accession: NZ_CP018245
• Organism: Escherichia coli strain 472

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: BFL23_RS24940
• Protein ID: WP_001295224.1
• Coordinates: 4485132..4485239 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	agrB
Locus tag	-
Coordinates	4485288..4485353 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BFL23_RS24915	4480385..4481137	-	753	Protein_4408	cellulose biosynthesis protein BcsQ	-
BFL23_RS24920	4481149..4481337	-	189	WP_001063316.1	YhjR family protein	-
BFL23_RS24925	4481610..4483181	+	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
BFL23_RS24930	4483178..4483369	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
BFL23_RS24935	4483366..4485045	+	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
BFL23_RS24940	4485132..4485239	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4485288..4485353	+	66	NuclAT_17	-	Antitoxin
-	4485288..4485353	+	66	NuclAT_17	-	Antitoxin
-	4485288..4485353	+	66	NuclAT_17	-	Antitoxin
-	4485288..4485353	+	66	NuclAT_17	-	Antitoxin
-	4485288..4485353	+	66	NuclAT_22	-	Antitoxin
-	4485288..4485353	+	66	NuclAT_22	-	Antitoxin
-	4485288..4485353	+	66	NuclAT_22	-	Antitoxin
-	4485288..4485353	+	66	NuclAT_22	-	Antitoxin
BFL23_RS24955	4485715..4486986	+	1272	WP_001301684.1	amino acid permease	-
BFL23_RS24960	4487016..4488020	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
BFL23_RS24965	4488017..4489000	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
BFL23_RS24970	4489011..4489913	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T69163 WP_001295224.1 NZ_CP018245:c4485239-4485132 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T69163 NZ_CP018245:c4485239-4485132 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT69163 NZ_CP018245:4485288-4485353 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin