Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1405994..1406789 Replicon chromosome
Accession NZ_CP018245
Organism Escherichia coli strain 472

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag BFL23_RS07420 Protein ID WP_000854914.1
Coordinates 1406415..1406789 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag BFL23_RS07415 Protein ID WP_001280954.1
Coordinates 1405994..1406368 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFL23_RS07370 1401349..1402254 + 906 WP_000203541.1 chemotaxis protein -
BFL23_RS07375 1402251..1403321 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
BFL23_RS07390 1403661..1404479 + 819 WP_001234682.1 DUF945 domain-containing protein -
BFL23_RS07395 1404570..1405055 + 486 WP_000214398.1 antirestriction protein -
BFL23_RS07400 1405071..1405547 + 477 WP_001186738.1 RadC family protein -
BFL23_RS07405 1405610..1405831 + 222 WP_001220314.1 DUF987 domain-containing protein -
BFL23_RS07415 1405994..1406368 + 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BFL23_RS07420 1406415..1406789 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
BFL23_RS07425 1406786..1407277 + 492 WP_000976853.1 hypothetical protein -
BFL23_RS07430 1407289..1407486 + 198 WP_000839282.1 DUF957 domain-containing protein -
BFL23_RS07435 1407571..1408413 + 843 WP_001280481.1 DUF4942 domain-containing protein -
BFL23_RS07445 1408884..1409822 + 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
BFL23_RS07450 1409877..1410614 + 738 WP_000283664.1 zinc-binding phosphatase -
BFL23_RS07455 1410638..1411192 + 555 WP_001001917.1 molecular chaperone YcdY -
BFL23_RS07460 1411294..1411785 + 492 WP_001301587.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 1405071..1417353 12282


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T69144 WP_000854914.1 NZ_CP018245:1406415-1406789 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T69144 NZ_CP018245:1406415-1406789 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT69144 WP_001280954.1 NZ_CP018245:1405994-1406368 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT69144 NZ_CP018245:1405994-1406368 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References