Detailed information of TA system TA069128

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-ohsC/Ldr(toxin)
• Location: 4380966..4381187
• Replicon: chromosome
• Accession: NZ_CP018243
• Organism: Escherichia coli strain 350

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: BFL21_RS24100
• Protein ID: WP_001295224.1
• Coordinates: 4380966..4381073 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	4381122..4381187 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BFL21_RS24075	4376219..4376971	-	753	Protein_4264	cellulose biosynthesis protein BcsQ	-
BFL21_RS24080	4376983..4377171	-	189	WP_001063316.1	YhjR family protein	-
BFL21_RS24085	4377444..4379015	+	1572	WP_001204925.1	cellulose biosynthesis protein BcsE	-
BFL21_RS24090	4379012..4379203	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
BFL21_RS24095	4379200..4380879	+	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
BFL21_RS24100	4380966..4381073	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4381122..4381187	+	66	NuclAT_16	-	Antitoxin
-	4381122..4381187	+	66	NuclAT_16	-	Antitoxin
-	4381122..4381187	+	66	NuclAT_16	-	Antitoxin
-	4381122..4381187	+	66	NuclAT_16	-	Antitoxin
-	4381122..4381187	+	66	NuclAT_21	-	Antitoxin
-	4381122..4381187	+	66	NuclAT_21	-	Antitoxin
-	4381122..4381187	+	66	NuclAT_21	-	Antitoxin
-	4381122..4381187	+	66	NuclAT_21	-	Antitoxin
BFL21_RS24115	4381549..4382820	+	1272	WP_001301684.1	amino acid permease	-
BFL21_RS24120	4382850..4383854	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
BFL21_RS24125	4383851..4384834	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
BFL21_RS24130	4384845..4385747	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T69128 WP_001295224.1 NZ_CP018243:c4381073-4380966 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T69128 NZ_CP018243:c4381073-4380966 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT69128 NZ_CP018243:4381122-4381187 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin