Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 5413730..5414142 Replicon chromosome
Accession NZ_CP018241
Organism Escherichia coli strain 319

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag BFL24_RS29455 Protein ID WP_000132630.1
Coordinates 5413730..5414071 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 5414066..5414142 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFL24_RS32080 5409298..5409498 + 201 WP_001310455.1 hypothetical protein -
BFL24_RS29430 5409741..5411153 - 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
BFL24_RS29440 5411330..5411494 + 165 WP_000394274.1 DUF1127 domain-containing protein -
BFL24_RS29445 5411591..5412472 + 882 WP_001304007.1 DUF262 domain-containing protein -
BFL24_RS29450 5412520..5413683 + 1164 WP_001304006.1 DUF1524 domain-containing protein -
BFL24_RS29455 5413730..5414071 - 342 WP_000132630.1 endoribonuclease SymE Toxin
- 5414066..5414142 + 77 NuclAT_13 - Antitoxin
- 5414066..5414142 + 77 NuclAT_13 - Antitoxin
- 5414066..5414142 + 77 NuclAT_13 - Antitoxin
- 5414066..5414142 + 77 NuclAT_13 - Antitoxin
- 5414066..5414142 + 77 NuclAT_14 - Antitoxin
- 5414066..5414142 + 77 NuclAT_14 - Antitoxin
- 5414066..5414142 + 77 NuclAT_14 - Antitoxin
- 5414066..5414142 + 77 NuclAT_14 - Antitoxin
BFL24_RS29460 5414292..5416046 - 1755 WP_000110094.1 restriction endonuclease subunit S -
BFL24_RS29465 5416046..5417515 - 1470 WP_001302468.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 5403223..5421943 18720


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T69090 WP_000132630.1 NZ_CP018241:c5414071-5413730 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T69090 NZ_CP018241:c5414071-5413730 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT69090 NZ_CP018241:5414066-5414142 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References