Detailed information of TA system TA069085

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-ohsC/Ldr(toxin)
• Location: 4408699..4408920
• Replicon: chromosome
• Accession: NZ_CP018241
• Organism: Escherichia coli strain 319

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: BFL24_RS24125
• Protein ID: WP_001295224.1
• Coordinates: 4408699..4408806 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	4408855..4408920 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BFL24_RS24100	4403952..4404704	-	753	Protein_4277	cellulose biosynthesis protein BcsQ	-
BFL24_RS24105	4404716..4404904	-	189	WP_001063316.1	YhjR family protein	-
BFL24_RS24110	4405177..4406748	+	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
BFL24_RS24115	4406745..4406936	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
BFL24_RS24120	4406933..4408612	+	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
BFL24_RS24125	4408699..4408806	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4408855..4408920	+	66	NuclAT_15	-	Antitoxin
-	4408855..4408920	+	66	NuclAT_15	-	Antitoxin
-	4408855..4408920	+	66	NuclAT_15	-	Antitoxin
-	4408855..4408920	+	66	NuclAT_15	-	Antitoxin
-	4408855..4408920	+	66	NuclAT_20	-	Antitoxin
-	4408855..4408920	+	66	NuclAT_20	-	Antitoxin
-	4408855..4408920	+	66	NuclAT_20	-	Antitoxin
-	4408855..4408920	+	66	NuclAT_20	-	Antitoxin
BFL24_RS24140	4409282..4410553	+	1272	WP_001301684.1	amino acid permease	-
BFL24_RS24145	4410583..4411587	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
BFL24_RS24150	4411584..4412567	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
BFL24_RS24155	4412578..4413480	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T69085 WP_001295224.1 NZ_CP018241:c4408806-4408699 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T69085 NZ_CP018241:c4408806-4408699 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT69085 NZ_CP018241:4408855-4408920 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin