69005

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-istR/SymE(toxin)
Location 5451848..5452260 Replicon chromosome
Accession NZ_CP018237
Organism Escherichia coli strain 155

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag BFL20_RS29855 Protein ID WP_000132630.1
Coordinates 5451848..5452189 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name istR
Locus tag -
Coordinates 5452184..5452260 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFL20_RS32435 5447416..5447616 + 201 WP_001310455.1 hypothetical protein -
BFL20_RS29830 5447859..5449271 - 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
BFL20_RS29840 5449448..5449612 + 165 WP_000394274.1 DUF1127 domain-containing protein -
BFL20_RS29845 5449709..5450590 + 882 WP_001304007.1 DUF262 domain-containing protein -
BFL20_RS29850 5450638..5451801 + 1164 WP_001304006.1 DUF1524 domain-containing protein -
BFL20_RS29855 5451848..5452189 - 342 WP_000132630.1 endoribonuclease SymE Toxin
- 5452184..5452260 + 77 NuclAT_15 - Antitoxin
- 5452184..5452260 + 77 NuclAT_15 - Antitoxin
- 5452184..5452260 + 77 NuclAT_15 - Antitoxin
- 5452184..5452260 + 77 NuclAT_15 - Antitoxin
- 5452184..5452260 + 77 NuclAT_16 - Antitoxin
- 5452184..5452260 + 77 NuclAT_16 - Antitoxin
- 5452184..5452260 + 77 NuclAT_16 - Antitoxin
- 5452184..5452260 + 77 NuclAT_16 - Antitoxin
BFL20_RS29860 5452410..5454164 - 1755 WP_000110082.1 restriction endonuclease subunit S -
BFL20_RS29865 5454164..5455633 - 1470 WP_001302468.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 5441341..5460061 18720


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T69005 WP_000132630.1 NZ_CP018237:c5452189-5451848 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T69005 NZ_CP018237:c5452189-5451848 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT69005 NZ_CP018237:5452184-5452260 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References