Detailed information of TA system TA069001

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-agrB/Ldr(toxin)
• Location: 4473525..4473746
• Replicon: chromosome
• Accession: NZ_CP018237
• Organism: Escherichia coli strain 155

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: BFL20_RS24820
• Protein ID: WP_001295224.1
• Coordinates: 4473525..4473632 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	agrB
Locus tag	-
Coordinates	4473681..4473746 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BFL20_RS24795	4468778..4469530	-	753	Protein_4398	cellulose biosynthesis protein BcsQ	-
BFL20_RS24800	4469542..4469730	-	189	WP_001063316.1	YhjR family protein	-
BFL20_RS24805	4470003..4471574	+	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
BFL20_RS24810	4471571..4471762	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
BFL20_RS24815	4471759..4473438	+	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
BFL20_RS24820	4473525..4473632	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4473681..4473746	+	66	NuclAT_17	-	Antitoxin
-	4473681..4473746	+	66	NuclAT_17	-	Antitoxin
-	4473681..4473746	+	66	NuclAT_17	-	Antitoxin
-	4473681..4473746	+	66	NuclAT_17	-	Antitoxin
-	4473681..4473746	+	66	NuclAT_22	-	Antitoxin
-	4473681..4473746	+	66	NuclAT_22	-	Antitoxin
-	4473681..4473746	+	66	NuclAT_22	-	Antitoxin
-	4473681..4473746	+	66	NuclAT_22	-	Antitoxin
BFL20_RS24835	4474108..4475380	+	1273	Protein_4404	transporter	-
BFL20_RS24840	4475410..4476414	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
BFL20_RS24845	4476411..4477394	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
BFL20_RS24850	4477405..4478307	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T69001 WP_001295224.1 NZ_CP018237:c4473632-4473525 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T69001 NZ_CP018237:c4473632-4473525 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT69001 NZ_CP018237:4473681-4473746 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin