Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1395351..1396146 Replicon chromosome
Accession NZ_CP018237
Organism Escherichia coli strain 155

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag BFL20_RS07300 Protein ID WP_000854914.1
Coordinates 1395772..1396146 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag BFL20_RS07295 Protein ID WP_001280954.1
Coordinates 1395351..1395725 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFL20_RS07250 1390706..1391611 + 906 WP_000203541.1 chemotaxis protein -
BFL20_RS07255 1391608..1392678 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
BFL20_RS07270 1393018..1393836 + 819 WP_001234682.1 DUF945 domain-containing protein -
BFL20_RS07275 1393927..1394412 + 486 WP_000214398.1 antirestriction protein -
BFL20_RS07280 1394428..1394904 + 477 WP_001186738.1 RadC family protein -
BFL20_RS07285 1394967..1395188 + 222 WP_001220314.1 DUF987 domain-containing protein -
BFL20_RS07295 1395351..1395725 + 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BFL20_RS07300 1395772..1396146 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
BFL20_RS07305 1396143..1396634 + 492 WP_000976853.1 hypothetical protein -
BFL20_RS07310 1396646..1396843 + 198 WP_000839282.1 DUF957 domain-containing protein -
BFL20_RS07315 1396928..1397770 + 843 WP_001280481.1 DUF4942 domain-containing protein -
BFL20_RS07325 1398241..1399179 + 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
BFL20_RS07330 1399234..1399971 + 738 WP_000283664.1 zinc-binding phosphatase -
BFL20_RS07335 1399995..1400549 + 555 WP_001001917.1 molecular chaperone YcdY -
BFL20_RS07340 1400651..1401142 + 492 WP_001301587.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 1394428..1406710 12282


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T68974 WP_000854914.1 NZ_CP018237:1395772-1396146 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T68974 NZ_CP018237:1395772-1396146 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT68974 WP_001280954.1 NZ_CP018237:1395351-1395725 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT68974 NZ_CP018237:1395351-1395725 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References