Detailed information of TA system TA068881

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1797215..1797727
• Replicon: chromosome
• Accession: NZ_CP018189
• Organism: Streptococcus salivarius strain ICDC3

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: W3XTH0
• Locus tag: BSR20_RS08250
• Protein ID: WP_014634942.1
• Coordinates: 1797215..1797469 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: BSR20_RS08255
• Protein ID: WP_013991075.1
• Coordinates: 1797473..1797727 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BSR20_RS08235	1792738..1793103	-	366	WP_156209922.1	hypothetical protein	-
BSR20_RS08240	1793196..1793804	-	609	WP_002884297.1	DUF4230 domain-containing protein	-
BSR20_RS08245	1794384..1796489	-	2106	WP_049529235.1	ATP-dependent Clp protease ATP-binding subunit	-
BSR20_RS08250	1797215..1797469	-	255	WP_014634942.1	Txe/YoeB family addiction module toxin	Toxin
BSR20_RS08255	1797473..1797727	-	255	WP_013991075.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
BSR20_RS08260	1797889..1800888	-	3000	WP_156209923.1	type I restriction endonuclease subunit R	-
BSR20_RS08265	1800953..1802449	-	1497	WP_156209924.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1792738..1804823	12085

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10111.55 Da
• Isoelectric Point: 8.8499

>T68881 WP_014634942.1 NZ_CP018189:c1797469-1797215 [Streptococcus salivarius]
MLLTFTEDAWTDYCYWQNQDRKTLKRINKLIKDIQRDPFSGIGKPEPLKYDFQGAWSRRIDAENRLIYMIDGKSVAFLSF
KDHY

Nucleotide

• Length: 255 bp

>T68881 NZ_CP018189:c1797469-1797215 [Streptococcus salivarius]
ATGTTACTCACTTTTACTGAAGATGCATGGACAGATTATTGTTATTGGCAAAATCAGGATAGGAAGACACTTAAACGAAT
CAATAAGCTGATTAAAGATATTCAGCGGGATCCTTTTTCAGGTATTGGTAAGCCAGAACCCTTAAAGTATGACTTTCAAG
GAGCTTGGTCTCGACGAATTGATGCTGAAAATCGTTTGATTTATATGATTGATGGTAAGAGCGTCGCTTTTCTATCTTTT
AAAGATCATTATTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9719.00 Da
• Isoelectric Point: 4.8782

>AT68881 WP_013991075.1 NZ_CP018189:c1797727-1797473 [Streptococcus salivarius]
MEAVVYSTFRNHLKDYMKKVNDEFEPLAVVNKNPDEDIVVVSKSEWDSIQETLRIVQNKELSDKVLRGMAQVRAGETQEH
AIKE

Nucleotide

• Length: 255 bp

>AT68881 NZ_CP018189:c1797727-1797473 [Streptococcus salivarius]
ATGGAAGCAGTCGTCTATTCAACGTTTCGAAATCATTTAAAGGATTATATGAAGAAGGTTAATGATGAATTTGAACCTCT
AGCTGTAGTTAATAAAAATCCTGATGAAGATATTGTAGTGGTCTCAAAGAGTGAATGGGATAGCATTCAAGAAACATTGC
GTATTGTTCAAAATAAAGAACTATCAGACAAGGTTTTAAGAGGAATGGCTCAGGTACGTGCTGGAGAGACTCAAGAACAT
GCAATAAAGGAGTAG

Structures

Toxin

• AlphaFold DB: W3XTH0