Detailed information of TA system TA068877

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-couple_hipB
• Location: 779541..780189
• Replicon: chromosome
• Accession: NZ_CP018187
• Organism: Streptococcus salivarius strain ICDC2

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: BSR19_RS04030
• Protein ID: WP_156247079.1
• Coordinates: 779541..779906 (+)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: BSR19_RS04035
• Protein ID: WP_021144391.1
• Coordinates: 779896..780189 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BSR19_RS04020	776921..778054	+	1134	WP_156246616.1	phage abortive infection protein	-
BSR19_RS04025	778176..779375	+	1200	WP_197092258.1	restriction endonuclease subunit S	-
BSR19_RS04030	779541..779906	+	366	WP_156247079.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BSR19_RS04035	779896..780189	+	294	WP_021144391.1	helix-turn-helix transcriptional regulator	Antitoxin
BSR19_RS04040	780211..781812	+	1602	WP_156246618.1	type I restriction-modification system subunit M	-
BSR19_RS04045	781891..782802	+	912	WP_037597651.1	Rpn family recombination-promoting nuclease/putative transposase	-
BSR19_RS04050	782829..783086	+	258	WP_002890620.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (36-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-88)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 14483.64 Da
• Isoelectric Point: 9.3276

>T68877 WP_156247079.1 NZ_CP018187:779541-779906 [Streptococcus salivarius]
VHAIYFYKDKQGNQPVLDYMRELARHDSKDSRIKLNKLNDYIELLSQHGTCAGQPYIKHLDAEIWELRPLRDRILFVAWL
DGSFVLLHHFVKKTQKTPRREIEKAKRELQDLKERGLKDEE

Nucleotide

• Length: 366 bp

>T68877 NZ_CP018187:779541-779906 [Streptococcus salivarius]
GTGCACGCTATTTATTTTTATAAGGACAAACAGGGGAATCAACCGGTCTTGGACTACATGAGAGAGCTAGCTCGTCACGA
TAGCAAGGACAGCCGGATCAAACTCAACAAGCTCAACGACTACATCGAACTTTTGAGTCAACATGGTACCTGTGCTGGCC
AACCCTATATCAAGCATCTGGATGCAGAGATTTGGGAGTTGAGACCCTTGCGGGATCGGATTTTATTCGTGGCTTGGTTG
GATGGAAGCTTTGTCTTACTGCATCATTTTGTCAAAAAGACGCAAAAGACACCTAGACGAGAGATCGAGAAAGCCAAGCG
GGAGTTGCAAGATTTGAAGGAAAGAGGGCTAAAAGATGAAGAATAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10730.48 Da
• Isoelectric Point: 5.8962

>AT68877 WP_021144391.1 NZ_CP018187:779896-780189 [Streptococcus salivarius]
MKNSAIGSNWKDVRAELFTKEEILESDLRVAIMTELIEARHEKGISQKKLEELSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEQEKV

Nucleotide

• Length: 294 bp

>AT68877 NZ_CP018187:779896-780189 [Streptococcus salivarius]
ATGAAGAATAGTGCCATTGGCAGCAATTGGAAAGATGTGAGAGCAGAGCTCTTCACAAAGGAAGAAATCCTGGAAAGTGA
TCTGCGGGTCGCGATTATGACTGAGCTGATCGAAGCTCGGCATGAAAAGGGCATTAGCCAAAAGAAACTAGAAGAACTCA
GTGGGGTCAGTCAACCGGTCATCGCTCGGATGGAGACAGGAAAGACCAGCCCTCAATTGGACACGGTCTTGAAAGTCTTA
GCCAGTCTGGGCAAGACCCTTGCTGTCGTCCCACTGGAACAAGAAAAGGTCTAA