Detailed information of TA system TA068875

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1797220..1797732
• Replicon: chromosome
• Accession: NZ_CP018186
• Organism: Streptococcus salivarius strain ICDC1

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: W3XTH0
• Locus tag: BSR14_RS08245
• Protein ID: WP_014634942.1
• Coordinates: 1797220..1797474 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: BSR14_RS08250
• Protein ID: WP_013991075.1
• Coordinates: 1797478..1797732 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BSR14_RS08230	1792743..1793108	-	366	WP_156209922.1	hypothetical protein	-
BSR14_RS08235	1793201..1793809	-	609	WP_002884297.1	DUF4230 domain-containing protein	-
BSR14_RS08240	1794389..1796494	-	2106	WP_049529235.1	ATP-dependent Clp protease ATP-binding subunit	-
BSR14_RS08245	1797220..1797474	-	255	WP_014634942.1	Txe/YoeB family addiction module toxin	Toxin
BSR14_RS08250	1797478..1797732	-	255	WP_013991075.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
BSR14_RS08255	1797894..1800893	-	3000	WP_156209923.1	type I restriction endonuclease subunit R	-
BSR14_RS08260	1800958..1802454	-	1497	WP_156209924.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1792743..1804828	12085

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10111.55 Da
• Isoelectric Point: 8.8499

>T68875 WP_014634942.1 NZ_CP018186:c1797474-1797220 [Streptococcus salivarius]
MLLTFTEDAWTDYCYWQNQDRKTLKRINKLIKDIQRDPFSGIGKPEPLKYDFQGAWSRRIDAENRLIYMIDGKSVAFLSF
KDHY

Nucleotide

• Length: 255 bp

>T68875 NZ_CP018186:c1797474-1797220 [Streptococcus salivarius]
ATGTTACTCACTTTTACTGAAGATGCATGGACAGATTATTGTTATTGGCAAAATCAGGATAGGAAGACACTTAAACGAAT
CAATAAGCTGATTAAAGATATTCAGCGGGATCCTTTTTCAGGTATTGGTAAGCCAGAACCCTTAAAGTATGACTTTCAAG
GAGCTTGGTCTCGACGAATTGATGCTGAAAATCGTTTGATTTATATGATTGATGGTAAGAGCGTCGCTTTTCTATCTTTT
AAAGATCATTATTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9719.00 Da
• Isoelectric Point: 4.8782

>AT68875 WP_013991075.1 NZ_CP018186:c1797732-1797478 [Streptococcus salivarius]
MEAVVYSTFRNHLKDYMKKVNDEFEPLAVVNKNPDEDIVVVSKSEWDSIQETLRIVQNKELSDKVLRGMAQVRAGETQEH
AIKE

Nucleotide

• Length: 255 bp

>AT68875 NZ_CP018186:c1797732-1797478 [Streptococcus salivarius]
ATGGAAGCAGTCGTCTATTCAACGTTTCGAAATCATTTAAAGGATTATATGAAGAAGGTTAATGATGAATTTGAACCTCT
AGCTGTAGTTAATAAAAATCCTGATGAAGATATTGTAGTGGTCTCAAAGAGTGAATGGGATAGCATTCAAGAAACATTGC
GTATTGTTCAAAATAAAGAACTATCAGACAAGGTTTTAAGAGGAATGGCTCAGGTACGTGCTGGAGAGACTCAAGAACAT
GCAATAAAGGAGTAG

Structures

Toxin

• AlphaFold DB: W3XTH0