Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1660424..1660936 Replicon chromosome
Accession NZ_CP018136
Organism Streptococcus pneumoniae strain SP49

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag BMJ42_RS09220 Protein ID WP_000924721.1
Coordinates 1660424..1660678 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag BMJ42_RS09225 Protein ID WP_000388572.1
Coordinates 1660682..1660936 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMJ42_RS09205 1657525..1657839 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
BMJ42_RS09210 1657864..1658490 - 627 WP_000775037.1 guanylate kinase -
BMJ42_RS09215 1658620..1660233 - 1614 WP_000404940.1 ribonuclease Y -
BMJ42_RS09220 1660424..1660678 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
BMJ42_RS09225 1660682..1660936 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BMJ42_RS09230 1661174..1662271 - 1098 WP_073177206.1 nucleotidyltransferase -
BMJ42_RS09235 1662281..1663021 - 741 WP_000257066.1 class I SAM-dependent methyltransferase -
BMJ42_RS09240 1663341..1663694 - 354 WP_001003001.1 ribosome silencing factor -
BMJ42_RS09245 1663707..1664207 - 501 WP_000844707.1 cysteine hydrolase -
BMJ42_RS09250 1664208..1664801 - 594 WP_000121654.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
BMJ42_RS09255 1664801..1665430 - 630 WP_000151317.1 nicotinate-nucleotide adenylyltransferase -
BMJ42_RS09260 1665482..1665793 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T68833 WP_000924721.1 NZ_CP018136:c1660678-1660424 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T68833 NZ_CP018136:c1660678-1660424 [Streptococcus pneumoniae]
ATGCTGCTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAATCAGGATAAGAAAACGTTAAAAAGAAT
CAATAAACTAATCAAGGATATTCAACGTGATCCCTTTACAGGAATAGGTAAACCAGAACCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT68833 WP_000388572.1 NZ_CP018136:c1660936-1660682 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT68833 NZ_CP018136:c1660936-1660682 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTCCTTTCAAAGAGTGAGTGGGATAGTATCCAAGAAACCCTGA
GAATTGCTCAAAATAAGGAACTTTCTGATAAGGTTTTGCGAGGAATGGCTCAAGTTCGTGCTGGAAGTACTCAGGTCCAT
GTTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References