68809

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2994275..2995002 Replicon chromosome
Accession NZ_CP018121
Organism Escherichia coli strain MRSN346355

Toxin (Protein)


Gene name higB Uniprot ID A0A829L2T9
Locus tag BSG24_RS15445 Protein ID WP_001521139.1
Coordinates 2994691..2995002 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BSG24_RS15440 Protein ID WP_000126294.1
Coordinates 2994275..2994694 (-) Length 140 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSG24_RS15420 2989360..2989887 - 528 WP_001078777.1 electron transport protein HydN -
BSG24_RS15425 2990036..2991046 - 1011 WP_015912547.1 DNA-binding transcriptional regulator AscG -
BSG24_RS15430 2991306..2992763 + 1458 WP_020234027.1 PTS cellobiose/arbutin/salicin transporter subunit IIBC -
BSG24_RS15435 2992772..2994196 + 1425 WP_020234028.1 6-phospho-beta-glucosidase AscB -
BSG24_RS15440 2994275..2994694 - 420 WP_000126294.1 helix-turn-helix domain-containing protein Antitoxin
BSG24_RS15445 2994691..2995002 - 312 WP_001521139.1 type II toxin-antitoxin system HigB family toxin Toxin
BSG24_RS15450 2995169..2995639 - 471 WP_000132961.1 hydrogenase maturation peptidase HycI -
BSG24_RS15455 2995632..2996042 - 411 WP_001291918.1 formate hydrogenlyase assembly protein HycH -
BSG24_RS15460 2996039..2996806 - 768 WP_000067399.1 formate hydrogenlyase subunit HycG -
BSG24_RS15465 2996806..2997348 - 543 WP_000493785.1 formate hydrogenlyase subunit HycF -
BSG24_RS15470 2997358..2999067 - 1710 WP_001521140.1 formate hydrogenlyase subunit HycE -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12493.23 Da        Isoelectric Point: 9.4783

>T68809 WP_001521139.1 NZ_CP018121:c2995002-2994691 [Escherichia coli]
MHIISKAPFEECARKYPNDALALYSLYRVIKETDFSTPEEMRTAFPNLDNFRYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

>T68809 NZ_CP018121:c2995002-2994691 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTATACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15416.42 Da        Isoelectric Point: 4.4596

>AT68809 WP_000126294.1 NZ_CP018121:c2994694-2994275 [Escherichia coli]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp

>AT68809 NZ_CP018121:c2994694-2994275 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGTAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCCGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCGTTACTTCGTACGCTGATTGATCAACATAATCTGACCTACGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGTGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A829L2T9


Antitoxin

Source ID Structure

References