Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1375966..1376640 Replicon chromosome
Accession NZ_CP018101
Organism Delftia sp. HK171

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag BO996_RS06245 Protein ID WP_043789322.1
Coordinates 1376359..1376640 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag BO996_RS06240 Protein ID WP_012203141.1
Coordinates 1375966..1376277 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BO996_RS06230 1371455..1372477 + 1023 WP_071954289.1 type I-F CRISPR-associated endonuclease Cas1 -
BO996_RS06235 1372474..1375962 + 3489 WP_071954290.1 type I-F CRISPR-associated helicase Cas3 -
BO996_RS06240 1375966..1376277 - 312 WP_012203141.1 HigA family addiction module antidote protein Antitoxin
BO996_RS06245 1376359..1376640 - 282 WP_043789322.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BO996_RS06250 1376807..1378156 + 1350 WP_071954291.1 type I-F CRISPR-associated protein Csy1 -
BO996_RS06255 1378153..1379235 + 1083 WP_071954292.1 type I-F CRISPR-associated protein Csy2 -
BO996_RS06260 1379290..1380318 + 1029 WP_071954293.1 type I-F CRISPR-associated protein Csy3 -
BO996_RS06265 1380324..1380890 + 567 WP_065345397.1 type I-F CRISPR-associated endoribonuclease Cas6/Csy4 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-98)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10721.30 Da        Isoelectric Point: 8.5442

>T68691 WP_043789322.1 NZ_CP018101:c1376640-1376359 [Delftia sp. HK171]
MAITSFKCPETQRLFTSGKTRRFANIQSVAERKLAQLDAAVTLEFLRSPPGNRLEMLVGDRQGQHSIRINDQWRLCFVWT
EKGVVDVEIVDYH

Download         Length: 282 bp

>T68691 NZ_CP018101:c1376640-1376359 [Delftia sp. HK171]
ATGGCGATCACTTCCTTCAAGTGCCCGGAAACCCAGCGCCTGTTCACCAGCGGCAAGACCCGCCGGTTCGCCAACATCCA
GAGCGTGGCGGAGCGCAAGCTGGCTCAGTTGGATGCGGCTGTGACACTTGAATTTCTGCGCAGCCCTCCTGGCAATCGCC
TGGAAATGCTCGTGGGAGATCGGCAGGGCCAGCACAGCATCCGCATCAACGACCAGTGGCGCCTCTGCTTTGTCTGGACG
GAAAAGGGAGTGGTTGACGTAGAGATAGTGGATTACCACTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11615.32 Da        Isoelectric Point: 8.6927

>AT68691 WP_012203141.1 NZ_CP018101:c1376277-1375966 [Delftia sp. HK171]
MLKNGMRPIHPGEVLREDYLKPMDMSANALARHLHVPASRVNDIVLERRGITADTALRLSRFFGGDAQSWLNLQTAYDLR
TAELNAELQASVRQVHPMQLHTA

Download         Length: 312 bp

>AT68691 NZ_CP018101:c1376277-1375966 [Delftia sp. HK171]
ATGCTTAAAAACGGCATGCGCCCCATACACCCAGGTGAAGTCCTGCGCGAGGACTACCTGAAGCCCATGGACATGAGCGC
CAACGCGCTGGCCAGGCACCTGCACGTTCCCGCCTCGCGCGTGAACGACATCGTGCTGGAGCGGCGCGGCATCACGGCCG
ACACGGCGCTGCGGCTGAGCCGCTTCTTTGGGGGCGACGCGCAGTCCTGGCTGAACCTTCAGACCGCCTACGACCTGCGC
ACGGCAGAGCTGAACGCGGAGTTGCAGGCGTCCGTGAGGCAAGTTCATCCGATGCAGCTGCATACCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References