Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 312877..313552 Replicon chromosome
Accession NZ_CP018101
Organism Delftia sp. HK171

Toxin (Protein)


Gene name higB Uniprot ID A0A210VUD2
Locus tag BO996_RS01485 Protein ID WP_071953825.1
Coordinates 313169..313552 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID F6AKZ0
Locus tag BO996_RS01480 Protein ID WP_013800179.1
Coordinates 312877..313188 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BO996_RS01460 308512..309378 - 867 WP_034397802.1 ProQ/FinO family protein -
BO996_RS01465 309463..310713 - 1251 WP_013800181.1 glycolate oxidase subunit GlcF -
BO996_RS01470 310775..311557 - 783 WP_012202244.1 DUF1275 domain-containing protein -
BO996_RS01475 311583..312740 - 1158 WP_071953823.1 glycolate oxidase subunit GlcE -
BO996_RS01480 312877..313188 - 312 WP_013800179.1 helix-turn-helix transcriptional regulator Antitoxin
BO996_RS01485 313169..313552 - 384 WP_071953825.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BO996_RS01490 313750..315123 - 1374 WP_179217977.1 ammonium transporter -
BO996_RS01495 315155..315493 - 339 WP_012202241.1 P-II family nitrogen regulator -
BO996_RS01500 315517..316248 - 732 WP_013800176.1 TorF family putative porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14683.33 Da        Isoelectric Point: 4.9852

>T68689 WP_071953825.1 NZ_CP018101:c313552-313169 [Delftia sp. HK171]
MTQPWEVEYTDELGDWWADLTQAEQESIDASVRLLEARGPNLGYPHTSGIGSSRHPHMRELRVQHEGRPYRLLYAFDPRR
CAILLIGGDKTGDGRWYEVHVPIADRLYDTHLETLQKEGRIDGQEIQ

Download         Length: 384 bp

>T68689 NZ_CP018101:c313552-313169 [Delftia sp. HK171]
ATGACCCAGCCCTGGGAGGTGGAGTACACCGACGAGCTTGGCGACTGGTGGGCTGATCTGACGCAGGCCGAGCAGGAGTC
CATCGACGCATCGGTACGTCTGCTGGAGGCAAGAGGGCCGAATCTCGGATATCCCCATACGTCCGGCATCGGGAGTTCCA
GGCATCCGCACATGCGTGAGCTTCGTGTGCAACATGAGGGACGGCCTTACCGGCTGCTTTACGCGTTCGATCCGCGCCGC
TGCGCAATCTTGCTGATCGGCGGCGACAAAACGGGCGACGGCCGCTGGTATGAGGTGCACGTGCCCATTGCCGACCGGCT
GTACGACACCCACCTCGAAACCCTGCAAAAGGAAGGACGAATCGATGGCCAGGAAATTCAGTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11803.60 Da        Isoelectric Point: 9.8220

>AT68689 WP_013800179.1 NZ_CP018101:c313188-312877 [Delftia sp. HK171]
MARKFSELRARMSPEAQSRAAARAEAMLVEMQLQELRKARNVTQVEVARAMNVEQASISKLERREDMYVSTLREYVRALG
GELRLVASFPDADIQVHPFEPLR

Download         Length: 312 bp

>AT68689 NZ_CP018101:c313188-312877 [Delftia sp. HK171]
ATGGCCAGGAAATTCAGTGAACTGCGCGCCAGGATGTCGCCTGAGGCACAGTCCCGGGCCGCCGCGCGGGCCGAGGCCAT
GCTGGTGGAAATGCAGCTCCAGGAATTGCGCAAGGCCCGCAACGTGACACAGGTCGAAGTGGCCAGGGCCATGAACGTGG
AGCAAGCATCCATCTCCAAGCTGGAGCGCCGCGAGGACATGTACGTGAGCACGCTGCGCGAGTACGTCCGTGCGCTGGGC
GGCGAGCTGAGGCTGGTCGCCTCGTTTCCCGACGCCGACATCCAGGTCCATCCTTTCGAGCCTCTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A210VUD2

Antitoxin

Source ID Structure
AlphaFold DB A0A031I0J9

References