Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 1081730..1082312 | Replicon | chromosome |
| Accession | NZ_CP018091 | ||
| Organism | Synechococcus sp. SynAce01 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A1J0P981 |
| Locus tag | BM449_RS05740 | Protein ID | WP_071800444.1 |
| Coordinates | 1081730..1082023 (+) | Length | 98 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | BM449_RS05745 | Protein ID | WP_198949703.1 |
| Coordinates | 1082028..1082312 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BM449_RS15215 | 1076884..1077255 | + | 372 | WP_071800437.1 | hypothetical protein | - |
| BM449_RS15220 | 1077242..1077470 | + | 229 | Protein_1136 | BrnT family toxin | - |
| BM449_RS05695 | 1077430..1077636 | + | 207 | WP_071800438.1 | hypothetical protein | - |
| BM449_RS05700 | 1077648..1078109 | - | 462 | WP_205526855.1 | HNH endonuclease | - |
| BM449_RS05705 | 1078700..1078972 | + | 273 | WP_071800440.1 | DUF1778 domain-containing protein | - |
| BM449_RS05710 | 1078972..1079472 | + | 501 | WP_071800441.1 | GNAT family N-acetyltransferase | - |
| BM449_RS05715 | 1079759..1079956 | - | 198 | WP_071800442.1 | hypothetical protein | - |
| BM449_RS05720 | 1080232..1080498 | + | 267 | WP_083544624.1 | nucleotidyltransferase domain-containing protein | - |
| BM449_RS05725 | 1080539..1080847 | + | 309 | WP_083544625.1 | DUF86 domain-containing protein | - |
| BM449_RS05730 | 1081064..1081270 | + | 207 | WP_071802013.1 | 2-oxoisovalerate dehydrogenase | - |
| BM449_RS05735 | 1081267..1081475 | + | 209 | Protein_1145 | type II toxin-antitoxin system HicA family toxin | - |
| BM449_RS05740 | 1081730..1082023 | + | 294 | WP_071800444.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| BM449_RS05745 | 1082028..1082312 | + | 285 | WP_198949703.1 | HigA family addiction module antidote protein | Antitoxin |
| BM449_RS05750 | 1082385..1082585 | - | 201 | WP_145536939.1 | hypothetical protein | - |
| BM449_RS05755 | 1082693..1082926 | + | 234 | WP_071800447.1 | addiction module protein | - |
| BM449_RS15225 | 1083085..1083483 | - | 399 | WP_186437637.1 | hypothetical protein | - |
| BM449_RS05765 | 1083551..1083754 | + | 204 | WP_071800449.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| BM449_RS05770 | 1083751..1084152 | + | 402 | WP_071800450.1 | PIN domain-containing protein | - |
| BM449_RS05775 | 1084548..1084808 | - | 261 | WP_071802014.1 | hypothetical protein | - |
| BM449_RS05780 | 1085229..1086704 | + | 1476 | WP_071800451.1 | glycosyl hydrolase family 57 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1071666..1083215 | 11549 | |
| - | flank | IS/Tn | - | - | 1086953..1087906 | 953 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 11107.73 Da Isoelectric Point: 10.5734
>T68678 WP_071800444.1 NZ_CP018091:1081730-1082023 [Synechococcus sp. SynAce01]
VIRSFRCRDTQALFSGKPVRRFGSIARVAFRKLSLRKLAILDAAAGLNDLQIPPGNRLEPLRGDRHGQHSIRINDQFRLC
FHWTEAGPEDVEIVDYH
VIRSFRCRDTQALFSGKPVRRFGSIARVAFRKLSLRKLAILDAAAGLNDLQIPPGNRLEPLRGDRHGQHSIRINDQFRLC
FHWTEAGPEDVEIVDYH
Download Length: 294 bp
>T68678 NZ_CP018091:1081730-1082023 [Synechococcus sp. SynAce01]
GTGATCAGGTCGTTTCGTTGCCGAGACACCCAGGCCTTGTTTTCGGGAAAGCCGGTGCGGCGCTTTGGGAGCATCGCTCG
CGTGGCCTTCCGCAAGCTCTCCTTGCGCAAGCTCGCCATTCTTGATGCCGCCGCAGGCCTCAACGATCTGCAGATTCCAC
CAGGCAACCGCCTGGAGCCGCTCCGGGGAGACCGCCATGGCCAGCACAGCATCCGCATCAACGACCAGTTCCGGCTCTGC
TTTCACTGGACGGAAGCCGGGCCAGAGGATGTCGAAATCGTTGACTATCACTGA
GTGATCAGGTCGTTTCGTTGCCGAGACACCCAGGCCTTGTTTTCGGGAAAGCCGGTGCGGCGCTTTGGGAGCATCGCTCG
CGTGGCCTTCCGCAAGCTCTCCTTGCGCAAGCTCGCCATTCTTGATGCCGCCGCAGGCCTCAACGATCTGCAGATTCCAC
CAGGCAACCGCCTGGAGCCGCTCCGGGGAGACCGCCATGGCCAGCACAGCATCCGCATCAACGACCAGTTCCGGCTCTGC
TTTCACTGGACGGAAGCCGGGCCAGAGGATGTCGAAATCGTTGACTATCACTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10554.38 Da Isoelectric Point: 7.1664
>AT68678 WP_198949703.1 NZ_CP018091:1082028-1082312 [Synechococcus sp. SynAce01]
MLVHPGEVLLEEFLRPLGISQYRLAQAIDVPESRINAIVKGRRAITADTDLRLCRFFGLSEGFWLRMQGSHDLKLAKQAL
ESVLPAIEPIQPMA
MLVHPGEVLLEEFLRPLGISQYRLAQAIDVPESRINAIVKGRRAITADTDLRLCRFFGLSEGFWLRMQGSHDLKLAKQAL
ESVLPAIEPIQPMA
Download Length: 285 bp
>AT68678 NZ_CP018091:1082028-1082312 [Synechococcus sp. SynAce01]
ATGCTCGTTCACCCCGGCGAGGTGCTGCTGGAGGAGTTCTTGCGGCCATTGGGGATCAGCCAGTACCGGTTGGCGCAGGC
GATCGATGTGCCCGAGAGCCGCATCAACGCCATCGTGAAAGGGCGGCGGGCGATCACTGCCGACACCGATCTGCGCCTTT
GCCGGTTCTTTGGTCTGAGCGAGGGCTTCTGGCTGCGGATGCAAGGGAGCCATGATCTGAAGCTGGCCAAGCAGGCTCTG
GAAAGTGTGCTGCCGGCGATCGAGCCAATCCAGCCAATGGCGTGA
ATGCTCGTTCACCCCGGCGAGGTGCTGCTGGAGGAGTTCTTGCGGCCATTGGGGATCAGCCAGTACCGGTTGGCGCAGGC
GATCGATGTGCCCGAGAGCCGCATCAACGCCATCGTGAAAGGGCGGCGGGCGATCACTGCCGACACCGATCTGCGCCTTT
GCCGGTTCTTTGGTCTGAGCGAGGGCTTCTGGCTGCGGATGCAAGGGAGCCATGATCTGAAGCTGGCCAAGCAGGCTCTG
GAAAGTGTGCTGCCGGCGATCGAGCCAATCCAGCCAATGGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|