68650

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 125732..126240 Replicon chromosome
Accession NZ_CP018061
Organism Enterococcus mundtii strain DSM 4838

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2K8TBN6
Locus tag EM4838_RS00640 Protein ID WP_071866576.1
Coordinates 125971..126240 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2K8TBP2
Locus tag EM4838_RS00635 Protein ID WP_071866575.1
Coordinates 125732..125986 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EM4838_RS00615 121624..122265 + 642 WP_071866573.1 ABC transporter ATP-binding protein -
EM4838_RS00620 122283..122705 + 423 WP_065096980.1 hypothetical protein -
EM4838_RS00630 123760..125379 + 1620 WP_071866574.1 alpha-glucosidase -
EM4838_RS00635 125732..125986 + 255 WP_071866575.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EM4838_RS00640 125971..126240 + 270 WP_071866576.1 Txe/YoeB family addiction module toxin Toxin
EM4838_RS00645 126462..126896 + 435 WP_010736432.1 winged helix-turn-helix transcriptional regulator -
EM4838_RS00650 126993..128099 + 1107 WP_071866577.1 NADH-dependent flavin oxidoreductase -
EM4838_RS00655 128116..128793 + 678 WP_019722542.1 type 1 glutamine amidotransferase domain-containing protein -
EM4838_RS00660 128820..129680 + 861 WP_071866606.1 aldo/keto reductase -
EM4838_RS00665 129947..130471 - 525 WP_081367415.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-58)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10592.47 Da        Isoelectric Point: 10.3790

>T68650 WP_071866576.1 NZ_CP018061:125971-126240 [Enterococcus mundtii]
MGYLIEIKKNAKKDFTKLKSAGLHKKFDELLKVIRKNPFQSPPPYEKLVGIPYYSRRINIQHRLVYSVDIEREIVTILSV
WSHYERGLF

Download         Length: 270 bp

>T68650 NZ_CP018061:125971-126240 [Enterococcus mundtii]
TTGGGATACCTTATAGAAATTAAAAAAAATGCAAAAAAAGATTTTACTAAACTTAAAAGTGCAGGGTTACATAAAAAGTT
TGATGAATTACTCAAGGTCATTCGAAAGAATCCTTTTCAGTCACCGCCACCGTATGAAAAACTAGTAGGAATTCCGTATT
ACTCAAGAAGAATCAACATTCAGCATAGACTAGTTTATAGTGTGGACATTGAGAGGGAAATAGTAACAATTCTTTCCGTC
TGGTCTCATTATGAGCGTGGGTTGTTTTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9671.76 Da        Isoelectric Point: 4.0176

>AT68650 WP_071866575.1 NZ_CP018061:125732-125986 [Enterococcus mundtii]
MEVITPTKARNNLYSLIKHVVADNQPVEIINTKSEDESVVIISKADWNAIQETLYLQNTGVLNQIKHYEEEETEELGEID
WDTL

Download         Length: 255 bp

>AT68650 NZ_CP018061:125732-125986 [Enterococcus mundtii]
ATGGAAGTAATTACACCAACGAAGGCTCGAAATAATTTGTATAGCTTGATTAAGCATGTTGTGGCGGACAATCAACCGGT
TGAAATTATCAATACTAAAAGTGAAGATGAAAGTGTAGTAATTATTAGTAAGGCAGATTGGAATGCAATTCAGGAAACGC
TGTATTTACAAAATACAGGGGTACTTAATCAGATTAAGCACTACGAAGAGGAAGAAACGGAAGAGTTAGGTGAGATTGAT
TGGGATACCTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8TBN6

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8TBP2

References