Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3056788..3057296 Replicon chromosome
Accession NZ_CP018047
Organism Streptomyces niveus strain SCSIO 3406

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag BBN63_RS13220 Protein ID WP_078075550.1
Coordinates 3057036..3057296 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag BBN63_RS13215 Protein ID WP_078075549.1
Coordinates 3056788..3057039 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBN63_RS13175 3052422..3052769 - 348 WP_031230021.1 50S ribosomal protein L22 -
BBN63_RS13180 3052812..3053093 - 282 WP_023539342.1 30S ribosomal protein S19 -
BBN63_RS13185 3053106..3053942 - 837 WP_023539343.1 50S ribosomal protein L2 -
BBN63_RS13190 3053990..3054307 - 318 WP_078075546.1 50S ribosomal protein L23 -
BBN63_RS13195 3054307..3054966 - 660 WP_078075547.1 50S ribosomal protein L4 -
BBN63_RS13200 3054971..3055615 - 645 WP_078075548.1 50S ribosomal protein L3 -
BBN63_RS13205 3055630..3055938 - 309 WP_003948644.1 30S ribosomal protein S10 -
BBN63_RS13210 3056448..3056639 + 192 WP_078079541.1 DUF1059 domain-containing protein -
BBN63_RS13215 3056788..3057039 + 252 WP_078075549.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BBN63_RS13220 3057036..3057296 + 261 WP_078075550.1 Txe/YoeB family addiction module toxin Toxin
BBN63_RS13225 3057340..3057549 - 210 WP_078075551.1 DUF397 domain-containing protein -
BBN63_RS13230 3057546..3058514 - 969 WP_078075552.1 helix-turn-helix transcriptional regulator -
BBN63_RS13235 3058554..3059024 + 471 WP_078075553.1 ATP-binding protein -
BBN63_RS13240 3059119..3060015 + 897 WP_078075554.1 hypothetical protein -
BBN63_RS13245 3060044..3060289 + 246 WP_078079542.1 hypothetical protein -
BBN63_RS13250 3060758..3062278 + 1521 WP_203233718.1 methyltransferase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10275.61 Da        Isoelectric Point: 9.4245

>T68618 WP_078075550.1 NZ_CP018047:3057036-3057296 [Streptomyces niveus]
VKLVWSESAWDDYVWWQSEDRKVLKRINTLLQDVTRNGNEGIGKPEPLKHGFQGYWSRRITEEHRLVYKLAGDEVRIAAC
RYHYGR

Download         Length: 261 bp

>T68618 NZ_CP018047:3057036-3057296 [Streptomyces niveus]
GTGAAGCTCGTGTGGTCCGAGTCCGCCTGGGACGACTACGTGTGGTGGCAGTCGGAGGACCGAAAGGTTCTGAAGCGGAT
CAATACCCTTCTCCAGGACGTGACGCGCAACGGCAACGAGGGCATCGGGAAGCCGGAGCCGCTCAAGCACGGTTTCCAGG
GGTACTGGTCACGCCGTATCACTGAGGAACACCGTCTGGTCTACAAACTGGCGGGGGACGAGGTCCGGATCGCGGCCTGC
CGGTACCACTACGGCCGCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9304.36 Da        Isoelectric Point: 4.2696

>AT68618 WP_078075549.1 NZ_CP018047:3056788-3057039 [Streptomyces niveus]
MRTMSYTESRAKYAETLDSVVNDREEVIITRAGHDAVVMVALDDYESLKETAYLLRNPENARRLLASIDQLENGGGTVQE
LAE

Download         Length: 252 bp

>AT68618 NZ_CP018047:3056788-3057039 [Streptomyces niveus]
ATGAGGACGATGTCGTACACCGAGTCGCGGGCAAAGTATGCGGAGACGCTGGACTCGGTCGTCAACGACCGTGAAGAAGT
CATAATTACGAGAGCCGGGCACGATGCGGTCGTGATGGTGGCATTGGACGACTACGAGTCCCTCAAGGAAACGGCCTACC
TGCTCAGGAACCCTGAGAACGCCCGCCGCCTGCTGGCTTCGATCGACCAGCTCGAGAACGGCGGCGGCACAGTGCAGGAG
CTTGCCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References