Detailed information of TA system TA068603

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1544204..1544859
• Replicon: chromosome
• Accession: NZ_CP018037
• Organism: Bordetella pertussis strain J094

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: BOB46_RS07580
• Protein ID: WP_047122780.1
• Coordinates: 1544204..1544455 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: BOB46_RS07585
• Protein ID: WP_003809516.1
• Coordinates: 1544458..1544859 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BOB46_RS07555	1539365..1540495	-	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-
BOB46_RS07560	1540730..1541311	+	582	WP_019247931.1	molybdenum cofactor biosysynthesis protein	-
BOB46_RS07565	1541448..1542512	+	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
BOB46_RS07570	1542597..1543043	-	447	WP_003819827.1	GFA family protein	-
BOB46_RS07575	1543268..1544149	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
BOB46_RS07580	1544204..1544455	+	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
BOB46_RS07585	1544458..1544859	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
BOB46_RS07590	1544879..1545115	+	237	WP_010930404.1	membrane protein	-
BOB46_RS07595	1545123..1545602	+	480	WP_010930405.1	disulfide bond formation protein B	-
BOB46_RS07600	1545752..1546267	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
BOB46_RS07605	1546270..1547460	+	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
BOB46_RS07610	1547480..1548517	+	1038	WP_023853543.1	threonylcarbamoyl-AMP synthase	-
BOB46_RS07615	1548654..1549676	+	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T68603 WP_047122780.1 NZ_CP018037:1544204-1544455 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T68603 NZ_CP018037:1544204-1544455 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT68603 WP_003809516.1 NZ_CP018037:1544458-1544859 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT68603 NZ_CP018037:1544458-1544859 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6