Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1036768..1037411 Replicon chromosome
Accession NZ_CP018034
Organism Glaesserella parasuis str. Nagasaki

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag A2U21_RS05520 Protein ID WP_021109713.1
Coordinates 1036768..1037112 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A2U21_RS05525 Protein ID WP_021109712.1
Coordinates 1037115..1037411 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A2U21_RS05505 1032481..1033109 - 629 Protein_1032 transposase -
A2U21_RS05510 1033372..1034463 - 1092 WP_021109715.1 murein transglycosylase A -
A2U21_RS05515 1034574..1036553 - 1980 WP_021109714.1 exoribonuclease II -
A2U21_RS05520 1036768..1037112 + 345 WP_021109713.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A2U21_RS05525 1037115..1037411 + 297 WP_021109712.1 helix-turn-helix domain-containing protein Antitoxin
A2U21_RS05530 1037469..1038131 - 663 WP_021109711.1 Fic family protein -
A2U21_RS05535 1038211..1038999 - 789 WP_005714049.1 SDR family oxidoreductase -
A2U21_RS05540 1039242..1039868 + 627 WP_010786866.1 23S rRNA (uridine(2552)-2'-O)-methyltransferase RlmE -
A2U21_RS05545 1039942..1041870 + 1929 WP_021109710.1 ATP-dependent zinc metalloprotease FtsH -
A2U21_RS05550 1041839..1042081 + 243 WP_021109709.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(47-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-76)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13262.28 Da        Isoelectric Point: 7.9640

>T68594 WP_021109713.1 NZ_CP018034:1036768-1037112 [Glaesserella parasuis str. Nagasaki]
METEEYLTFIKTKVFEEDRKALMSDDEYQKFQAYLLESHELGDFIQNTGGCQKIRWKLESNNKGKSGGVRVIYYVVTKQG
KLLLMMMYAKSKQDNMSDKQKAMLKAVVSQLSEE

Download         Length: 345 bp

>T68594 NZ_CP018034:1036768-1037112 [Glaesserella parasuis str. Nagasaki]
ATGGAAACAGAAGAATATCTTACTTTTATTAAAACCAAAGTTTTTGAAGAAGACCGAAAAGCATTAATGTCTGATGATGA
ATATCAGAAATTTCAGGCTTATTTATTAGAATCTCACGAATTAGGCGATTTTATTCAGAATACTGGTGGTTGCCAAAAAA
TTCGCTGGAAACTAGAAAGTAATAACAAGGGCAAAAGTGGTGGTGTAAGGGTGATTTACTATGTTGTAACCAAACAGGGA
AAATTATTATTAATGATGATGTATGCTAAAAGCAAACAAGACAATATGAGTGATAAACAAAAAGCAATGTTAAAAGCGGT
TGTATCTCAATTAAGTGAGGAGTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11209.16 Da        Isoelectric Point: 10.0887

>AT68594 WP_021109712.1 NZ_CP018034:1037115-1037411 [Glaesserella parasuis str. Nagasaki]
MEKELFERLMESAREMVAIEKGEIEVPPHRIHIHKIPNVKAIRTLHQMKQAEFASLLGVSQNLVQSWEIGRRTPNGAARK
LLAIIEQQPNLVPVLQNL

Download         Length: 297 bp

>AT68594 NZ_CP018034:1037115-1037411 [Glaesserella parasuis str. Nagasaki]
ATGGAAAAAGAACTTTTTGAACGTCTAATGGAAAGTGCGAGAGAAATGGTCGCCATTGAAAAAGGCGAAATAGAAGTACC
ACCACATCGTATTCATATCCATAAAATCCCGAATGTTAAAGCGATTAGAACCCTGCATCAGATGAAACAAGCAGAATTTG
CTTCCCTTTTAGGCGTAAGCCAAAACCTTGTGCAGTCGTGGGAAATCGGCAGACGAACGCCAAATGGTGCGGCACGGAAA
TTGCTTGCGATTATTGAACAACAGCCTAATCTTGTCCCTGTACTTCAGAATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References