Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 1127586..1128147 | Replicon | chromosome |
Accession | NZ_CP018032 | ||
Organism | Glaesserella parasuis D74 |
Toxin (Protein)
Gene name | higB | Uniprot ID | U4SMA9 |
Locus tag | A2U20_RS05470 | Protein ID | WP_010786777.1 |
Coordinates | 1127869..1128147 (-) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | graA | Uniprot ID | - |
Locus tag | A2U20_RS05465 | Protein ID | WP_005712616.1 |
Coordinates | 1127586..1127858 (-) | Length | 91 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
A2U20_RS05450 | 1124109..1124651 | + | 543 | WP_021115958.1 | single-stranded DNA-binding protein | - |
A2U20_RS05455 | 1124805..1126292 | - | 1488 | WP_021116872.1 | DUF853 domain-containing protein | - |
A2U20_RS05460 | 1126302..1127522 | - | 1221 | WP_021116873.1 | ATP-dependent RNA helicase RhlB | - |
A2U20_RS05465 | 1127586..1127858 | - | 273 | WP_005712616.1 | HigA family addiction module antidote protein | Antitoxin |
A2U20_RS05470 | 1127869..1128147 | - | 279 | WP_010786777.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
A2U20_RS05475 | 1128296..1129306 | + | 1011 | WP_021116874.1 | ornithine carbamoyltransferase | - |
A2U20_RS11970 | 1129412..1129573 | - | 162 | WP_021116875.1 | hypothetical protein | - |
A2U20_RS05480 | 1129660..1130001 | - | 342 | WP_043895690.1 | hypothetical protein | - |
A2U20_RS05485 | 1130092..1130688 | - | 597 | WP_021116877.1 | hypothetical protein | - |
A2U20_RS05490 | 1131027..1132289 | + | 1263 | WP_021116878.1 | serine hydroxymethyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10278.66 Da Isoelectric Point: 10.0505
>T68585 WP_010786777.1 NZ_CP018032:c1128147-1127869 [Glaesserella parasuis D74]
MIISFKHKGLKLFFETGSTAGIQANHASKLAFQLATLNQAKSALDMNAPSWNLHQLQGNLAGHWSIKVSGNWRLTFKVQN
GHAEVVDYQDYH
MIISFKHKGLKLFFETGSTAGIQANHASKLAFQLATLNQAKSALDMNAPSWNLHQLQGNLAGHWSIKVSGNWRLTFKVQN
GHAEVVDYQDYH
Download Length: 279 bp
>T68585 NZ_CP018032:c1128147-1127869 [Glaesserella parasuis D74]
ATGATTATTTCATTTAAGCATAAAGGATTGAAATTATTTTTTGAAACAGGATCAACTGCAGGTATTCAGGCAAATCACGC
TAGTAAACTTGCTTTTCAATTAGCCACTCTAAACCAAGCAAAAAGTGCTTTAGATATGAATGCACCTAGCTGGAATTTAC
ATCAATTACAAGGTAATCTAGCTGGGCATTGGTCTATCAAGGTAAGTGGAAATTGGCGTTTAACTTTTAAAGTTCAAAAT
GGTCACGCTGAAGTCGTGGACTATCAAGATTATCATTAA
ATGATTATTTCATTTAAGCATAAAGGATTGAAATTATTTTTTGAAACAGGATCAACTGCAGGTATTCAGGCAAATCACGC
TAGTAAACTTGCTTTTCAATTAGCCACTCTAAACCAAGCAAAAAGTGCTTTAGATATGAATGCACCTAGCTGGAATTTAC
ATCAATTACAAGGTAATCTAGCTGGGCATTGGTCTATCAAGGTAAGTGGAAATTGGCGTTTAACTTTTAAAGTTCAAAAT
GGTCACGCTGAAGTCGTGGACTATCAAGATTATCATTAA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10314.06 Da Isoelectric Point: 9.8982
>AT68585 WP_005712616.1 NZ_CP018032:c1127858-1127586 [Glaesserella parasuis D74]
MKMYNPAHPGLILREYIEGYNVTEVAKRLGVTRVTLSRILNGKAAISPEMALRLSQLLKTSPELWLGLQSQYDLWQLEQR
PSFNIQPLFA
MKMYNPAHPGLILREYIEGYNVTEVAKRLGVTRVTLSRILNGKAAISPEMALRLSQLLKTSPELWLGLQSQYDLWQLEQR
PSFNIQPLFA
Download Length: 273 bp
>AT68585 NZ_CP018032:c1127858-1127586 [Glaesserella parasuis D74]
ATGAAAATGTACAATCCAGCTCACCCAGGGCTTATTTTAAGAGAATATATTGAAGGATATAATGTCACAGAAGTGGCTAA
ACGTTTAGGTGTCACTCGTGTCACGCTTTCTCGTATTTTAAATGGCAAAGCTGCAATTTCACCTGAAATGGCTCTTAGAT
TAAGCCAATTATTAAAAACTAGCCCAGAATTATGGCTTGGTTTACAATCCCAATACGATCTTTGGCAGCTTGAACAACGC
CCAAGTTTTAATATTCAGCCGTTATTTGCATAG
ATGAAAATGTACAATCCAGCTCACCCAGGGCTTATTTTAAGAGAATATATTGAAGGATATAATGTCACAGAAGTGGCTAA
ACGTTTAGGTGTCACTCGTGTCACGCTTTCTCGTATTTTAAATGGCAAAGCTGCAATTTCACCTGAAATGGCTCTTAGAT
TAAGCCAATTATTAAAAACTAGCCCAGAATTATGGCTTGGTTTACAATCCCAATACGATCTTTGGCAGCTTGAACAACGC
CCAAGTTTTAATATTCAGCCGTTATTTGCATAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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