Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 46842..47499 | Replicon | plasmid unnamed2 |
Accession | NZ_CP017987 | ||
Organism | Klebsiella pneumoniae strain 825795-1 |
Toxin (Protein)
Gene name | higB | Uniprot ID | U3PDC3 |
Locus tag | BB783_RS29295 | Protein ID | WP_000270043.1 |
Coordinates | 47149..47499 (-) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | BB783_RS29290 | Protein ID | WP_000124640.1 |
Coordinates | 46842..47144 (-) | Length | 101 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BB783_RS29240 | 42467..42895 | + | 429 | WP_000591074.1 | hypothetical protein | - |
BB783_RS29245 | 42952..43311 | + | 360 | WP_000422768.1 | hypothetical protein | - |
BB783_RS29250 | 43311..43757 | + | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
BB783_RS29255 | 43754..44272 | + | 519 | WP_000210756.1 | nitrite reductase | - |
BB783_RS29260 | 44272..44502 | + | 231 | WP_000972663.1 | hypothetical protein | - |
BB783_RS29265 | 44489..45346 | + | 858 | WP_001167032.1 | hypothetical protein | - |
BB783_RS29275 | 45577..46104 | + | 528 | WP_001236377.1 | thermonuclease family protein | - |
BB783_RS29280 | 46162..46434 | + | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
BB783_RS29285 | 46522..46815 | + | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
BB783_RS29290 | 46842..47144 | - | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
BB783_RS29295 | 47149..47499 | - | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
BB783_RS29300 | 47662..48210 | + | 549 | WP_001061574.1 | transcriptional regulator | - |
BB783_RS29310 | 48551..48745 | + | 195 | WP_000343597.1 | hypothetical protein | - |
BB783_RS29315 | 48756..49127 | + | 372 | WP_000516916.1 | hypothetical protein | - |
BB783_RS29320 | 49120..49590 | + | 471 | WP_001281821.1 | hypothetical protein | - |
BB783_RS29325 | 49605..49940 | - | 336 | WP_000683476.1 | hypothetical protein | - |
BB783_RS29330 | 50037..50525 | + | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
BB783_RS29335 | 50528..51025 | + | 498 | WP_000062185.1 | hypothetical protein | - |
BB783_RS29345 | 51240..51944 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
BB783_RS29350 | 52009..52188 | - | 180 | Protein_68 | helix-turn-helix transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | aac(6')-Ib / qacE / sul1 / floR / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 / blaOXA-48 | - | 1..117168 | 117168 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T68471 WP_000270043.1 NZ_CP017987:c47499-47149 [Klebsiella pneumoniae]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T68471 NZ_CP017987:c47499-47149 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT68471 WP_000124640.1 NZ_CP017987:c47144-46842 [Klebsiella pneumoniae]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT68471 NZ_CP017987:c47144-46842 [Klebsiella pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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