Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1995938..1996440 | Replicon | chromosome |
| Accession | NZ_CP017979 | ||
| Organism | Escherichia coli str. K-12 substr. W3110 strain K-12 substr. ZK126 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | BL257_RS10860 | Protein ID | WP_000767829.1 |
| Coordinates | 1995938..1996192 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | BL257_RS10865 | Protein ID | WP_001259255.1 |
| Coordinates | 1996189..1996440 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BL257_RS10835 (BL257_10105) | 1990953..1991180 | - | 228 | WP_000234896.1 | sulfurtransferase TusA | - |
| BL257_RS10840 (BL257_10110) | 1991194..1992252 | - | 1059 | WP_000492339.1 | transport protein YeeE | - |
| BL257_RS10845 (BL257_10115) | 1992431..1993789 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| BL257_RS24815 | 1993779..1993841 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
| BL257_RS10850 (BL257_10120) | 1994056..1994985 | - | 930 | WP_000803351.1 | LysR family transcriptional regulator | - |
| BL257_RS10855 (BL257_10125) | 1995031..1995855 | - | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| BL257_RS10860 (BL257_10130) | 1995938..1996192 | - | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| BL257_RS10865 (BL257_10135) | 1996189..1996440 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| BL257_RS10870 | 1996723..1996773 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
| BL257_RS10880 (BL257_10140) | 1996919..1997818 | + | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| BL257_RS10885 (BL257_10145) | 1997824..1999128 | + | 1305 | WP_000009594.1 | histidinol dehydrogenase | - |
| BL257_RS10890 (BL257_10150) | 1999125..2000195 | + | 1071 | WP_000108941.1 | histidinol-phosphate transaminase | - |
| BL257_RS10895 (BL257_10155) | 2000195..2001262 | + | 1068 | WP_000080105.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T68435 WP_000767829.1 NZ_CP017979:c1996192-1995938 [Escherichia coli str. K-12 substr. W3110]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T68435 NZ_CP017979:c1996192-1995938 [Escherichia coli str. K-12 substr. W3110]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT68435 WP_001259255.1 NZ_CP017979:c1996440-1996189 [Escherichia coli str. K-12 substr. W3110]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT68435 NZ_CP017979:c1996440-1996189 [Escherichia coli str. K-12 substr. W3110]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|