Detailed information of TA system TA068419

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 1196560..1196782
• Replicon: chromosome
• Accession: NZ_CP017979
• Organism: Escherichia coli str. K-12 substr. W3110 strain K-12 substr. ZK126

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: J7R083
• Locus tag: BL257_RS06510
• Protein ID: WP_000170963.1
• Coordinates: 1196560..1196667 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	1196715..1196782 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BL257_RS06475 (BL257_06015)	1191869..1192951	+	1083	WP_000804726.1	peptide chain release factor 1	-
BL257_RS06480 (BL257_06020)	1192951..1193784	+	834	WP_000456467.1	peptide chain release factor N(5)-glutamine methyltransferase	-
BL257_RS06485 (BL257_06025)	1193781..1194173	+	393	WP_000200374.1	invasion regulator SirB2	-
BL257_RS06490 (BL257_06030)	1194177..1194986	+	810	WP_001257044.1	invasion regulator SirB1	-
BL257_RS06495 (BL257_06035)	1195022..1195876	+	855	WP_000811065.1	3-deoxy-8-phosphooctulonate synthase	-
BL257_RS06500 (BL257_06040)	1196025..1196132	-	108	WP_000170955.1	small toxic polypeptide LdrA/LdrC	-
BL257_RS06510 (BL257_06045)	1196560..1196667	-	108	WP_000170963.1	small toxic polypeptide LdrB	Toxin
-	1196715..1196782	+	68	-	-	Antitoxin
BL257_RS06520 (BL257_06050)	1197095..1197202	-	108	WP_000170955.1	small toxic polypeptide LdrA/LdrC	-
BL257_RS06525 (BL257_06055)	1197606..1198706	-	1101	WP_000063607.1	sodium-potassium/proton antiporter ChaA	-
BL257_RS06530 (BL257_06060)	1198976..1199206	+	231	WP_001146444.1	putative cation transport regulator ChaB	-
BL257_RS06535 (BL257_06065)	1199364..1200059	+	696	WP_001336325.1	glutathione-specific gamma-glutamylcyclotransferase	-
BL257_RS06540 (BL257_06070)	1200103..1200456	-	354	WP_001169669.1	DsrE/F sulfur relay family protein YchN	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3971.74 Da
• Isoelectric Point: 11.4779

>T68419 WP_000170963.1 NZ_CP017979:c1196667-1196560 [Escherichia coli str. K-12 substr. W3110]
MTLAQFAMTFWHDLAAPILAGIITAAIVGWWRNRK

Nucleotide

• Length: 108 bp

>T68419 NZ_CP017979:c1196667-1196560 [Escherichia coli str. K-12 substr. W3110]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 68 bp

>AT68419 NZ_CP017979:1196715-1196782 [Escherichia coli str. K-12 substr. W3110]
GTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCTCT

Structures

Antitoxin