Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4803304..4803985 Replicon chromosome
Accession NZ_CP017969
Organism Pseudomonas aeruginosa isolate B10W

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BMR72_RS23270 Protein ID WP_015503432.1
Coordinates 4803620..4803985 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BMR72_RS23265 Protein ID WP_004364117.1
Coordinates 4803304..4803627 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMR72_RS23230 4799080..4799657 + 578 Protein_4477 plasmid pRiA4b ORF-3 family protein -
BMR72_RS32385 4801678..4802232 - 555 WP_074197746.1 tyrosine-type recombinase/integrase -
BMR72_RS32390 4802407..4802682 - 276 WP_004364115.1 hypothetical protein -
BMR72_RS23255 4802682..4803014 - 333 WP_016561578.1 hypothetical protein -
BMR72_RS32635 4803069..4803188 + 120 Protein_4482 IS5/IS1182 family transposase -
BMR72_RS23265 4803304..4803627 - 324 WP_004364117.1 XRE family transcriptional regulator Antitoxin
BMR72_RS23270 4803620..4803985 - 366 WP_015503432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BMR72_RS23275 4804249..4804488 - 240 WP_044069615.1 hypothetical protein -
BMR72_RS23280 4804695..4804967 + 273 WP_004364121.1 hypothetical protein -
BMR72_RS23285 4804998..4805423 - 426 WP_003116492.1 VOC family protein -
BMR72_RS23290 4805524..4806408 + 885 WP_004364122.1 LysR family transcriptional regulator -
BMR72_RS23295 4806381..4807334 - 954 WP_003085661.1 LysR family transcriptional regulator -
BMR72_RS23300 4807555..4807989 + 435 WP_003158601.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4769861..4805423 35562


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-86)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13798.14 Da        Isoelectric Point: 4.8219

>T68411 WP_015503432.1 NZ_CP017969:c4803985-4803620 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRPGHMRELRTQHGGRPFRTLYAFDPRRSA
ILPIGGDKTGDDRWYELNVPIADRLHDEHLHQLREEGLIDG

Download         Length: 366 bp

>T68411 NZ_CP017969:c4803985-4803620 [Pseudomonas aeruginosa]
GTGGCGTGGGATATCGAGTACACCGACGAGTTCGGTGATTGGTGGGGTTCTCTGTCCGAGGATGAGCAGGAGTCGCTAGC
TGTGACGGTTCGCTTGCTTGAGGAGCGGGGGCCATCCTTGGGGCACCCCCACAGCAGCGGCATCAATGGCTCCCGCCCTG
GCCATATGAGAGAGCTACGGACTCAACACGGCGGGCGACCTTTCCGAACGCTTTACGCGTTTGACCCCAGACGCTCCGCG
ATACTGCCGATCGGTGGCGACAAGACTGGCGATGATCGTTGGTACGAATTGAACGTGCCCATTGCCGACCGCCTCCATGA
CGAACACTTGCACCAGCTCCGTGAGGAGGGACTGATCGATGGCTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11896.73 Da        Isoelectric Point: 6.4751

>AT68411 WP_004364117.1 NZ_CP017969:c4803627-4803304 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLQVQQPAIAKMERRTDMYISTLRSHIEAMG
GHLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp

>AT68411 NZ_CP017969:c4803627-4803304 [Pseudomonas aeruginosa]
ATGGCTAAGAAATTCTCCGACCTTCGGGCGCAAATGTCGCCTGAGGCACAGGCCCGCGTCGAGGCCAAGGCCCAGGAACT
GTTGGCTGAAATGCCCCTGAATGAGTTGCGCCAGGCTAGAGGCTTGTCGCAGAAGATGCTGTCTGAAGTGCTGCAGGTGC
AGCAGCCGGCAATTGCCAAGATGGAGCGGCGTACGGATATGTACATCTCCACCTTGCGCAGCCACATCGAAGCCATGGGC
GGCCATCTGGAAGTGATTGCACGCTTCCCGGATGGCGCGGTGAAAATCAGCAACTTCGCTGATATCGAAGAGGCGGGCGC
CTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References