68290

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 400541..401189 Replicon chromosome
Accession NZ_CP017920
Organism Mycobacterium tuberculosis strain TB282

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag BK419_RS01900 Protein ID WP_003899414.1
Coordinates 400866..401189 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag BK419_RS01895 Protein ID WP_003899415.1
Coordinates 400541..400786 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BK419_RS01855 395689..395922 - 234 WP_003413717.1 hypothetical protein -
BK419_RS01860 396021..396293 - 273 WP_003900544.1 hypothetical protein -
BK419_RS20885 396199..396588 + 390 WP_003899422.1 hypothetical protein -
BK419_RS01865 396585..396812 + 228 WP_003899421.1 hypothetical protein -
BK419_RS01870 396957..398084 + 1128 WP_003899420.1 site-specific integrase -
BK419_RS01875 398087..398449 + 363 WP_003900543.1 hypothetical protein -
BK419_RS01880 398466..398726 + 261 WP_003899418.1 helix-turn-helix domain-containing protein -
BK419_RS01885 398723..399115 + 393 WP_003899417.1 DUF2742 domain-containing protein -
BK419_RS01890 399117..400544 + 1428 WP_003899416.1 DUF3631 domain-containing protein -
BK419_RS01895 400541..400786 + 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
BK419_RS01900 400866..401189 + 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
BK419_RS20890 401357..401848 + 492 WP_003900541.1 phage terminase small subunit P27 family -
BK419_RS01910 402001..402534 + 534 WP_003899412.1 HK97 family phage prohead protease -
BK419_RS01915 402542..403981 + 1440 WP_003901443.1 phage major capsid protein -
BK419_RS01920 404152..404403 - 252 WP_003908028.1 hypothetical protein -
BK419_RS01925 404391..404855 - 465 WP_003900539.1 ParB N-terminal domain-containing protein -
BK419_RS01930 404869..405867 - 999 WP_003900538.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 396957..405867 8910


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T68290 WP_003899414.1 NZ_CP017920:400866-401189 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T68290 NZ_CP017920:400866-401189 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT68290 WP_003899415.1 NZ_CP017920:400541-400786 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT68290 NZ_CP017920:400541-400786 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References