68262

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3986969..3987474 Replicon chromosome
Accession NZ_CP017886
Organism Pseudomonas frederiksbergensis strain ERDD5:01

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1J0EPA2
Locus tag BLL42_RS19145 Protein ID WP_071553477.1
Coordinates 3986969..3987223 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1J0ENM7
Locus tag BLL42_RS19150 Protein ID WP_071553478.1
Coordinates 3987220..3987474 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BLL42_RS19120 3982149..3982856 + 708 WP_071553472.1 peptide-methionine (S)-S-oxide reductase MsrA -
BLL42_RS19125 3982875..3983372 - 498 WP_071553473.1 GNAT family N-acetyltransferase -
BLL42_RS19130 3983497..3984510 - 1014 WP_071553474.1 sensor domain-containing diguanylate cyclase -
BLL42_RS19135 3984642..3985550 - 909 WP_071553475.1 LysR family transcriptional regulator -
BLL42_RS19140 3985653..3986834 + 1182 WP_071553476.1 aspartate aminotransferase family protein -
BLL42_RS19145 3986969..3987223 - 255 WP_071553477.1 Txe/YoeB family addiction module toxin Toxin
BLL42_RS19150 3987220..3987474 - 255 WP_071553478.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BLL42_RS19155 3987664..3988242 - 579 WP_071553479.1 DedA family protein -
BLL42_RS19160 3988326..3988778 - 453 WP_071553480.1 VOC family protein -
BLL42_RS19165 3988807..3989136 - 330 WP_071553481.1 hypothetical protein -
BLL42_RS19170 3989126..3989917 - 792 WP_071553482.1 VacJ family lipoprotein -
BLL42_RS19175 3990085..3990795 + 711 WP_071555797.1 response regulator -
BLL42_RS19180 3990804..3992147 + 1344 WP_071553483.1 HAMP domain-containing protein -
BLL42_RS19185 3992239..3992460 - 222 WP_071553484.1 formate dehydrogenase subunit delta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9933.50 Da        Isoelectric Point: 9.5036

>T68262 WP_071553477.1 NZ_CP017886:c3987223-3986969 [Pseudomonas frederiksbergensis]
MNILFTPEGWDDYLWFQQNDKAGLKRINLLIKATLRDPFAGPGKPEPLKHNLSGFWSRRITAEHRLVYTVEGEKLQIVMC
RYHY

Download         Length: 255 bp

>T68262 NZ_CP017886:c3987223-3986969 [Pseudomonas frederiksbergensis]
ATGAACATTCTGTTCACCCCCGAAGGCTGGGACGACTACCTCTGGTTTCAGCAGAACGATAAAGCCGGGCTCAAACGGAT
CAACCTGCTGATCAAGGCAACCCTGCGGGATCCGTTCGCAGGCCCTGGAAAGCCAGAGCCACTCAAACATAACCTTAGCG
GTTTTTGGTCCCGCAGGATCACTGCTGAGCATCGTCTGGTCTACACAGTAGAAGGTGAAAAACTACAGATCGTGATGTGC
AGATACCACTACTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9538.97 Da        Isoelectric Point: 8.5163

>AT68262 WP_071553478.1 NZ_CP017886:c3987474-3987220 [Pseudomonas frederiksbergensis]
MQTINYTNARAHLSETMDRVNEDRAPLLVTRQKGEPVVMISLAEYNALEETAYLLRTPANAERLIKSINSLRAGKTKPRL
LIEE

Download         Length: 255 bp

>AT68262 NZ_CP017886:c3987474-3987220 [Pseudomonas frederiksbergensis]
ATGCAAACCATTAATTACACCAATGCCCGGGCACACCTTTCCGAGACTATGGATCGAGTCAATGAAGACCGCGCCCCTCT
GTTGGTAACCCGGCAAAAAGGGGAACCGGTGGTGATGATTTCCCTTGCCGAATACAACGCCCTCGAAGAAACCGCCTACT
TGCTCCGTACTCCGGCCAACGCCGAGCGTCTGATCAAGTCGATCAACAGCCTGCGTGCGGGGAAAACCAAGCCAAGGCTG
CTCATTGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0EPA2

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0ENM7

References