Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1952297..1953096 Replicon chromosome
Accession NZ_CP017844
Organism Escherichia coli strain FMU073332

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag BLJ80_RS10615 Protein ID WP_000347273.1
Coordinates 1952297..1952761 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag BLJ80_RS10620 Protein ID WP_001307405.1
Coordinates 1952761..1953096 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BLJ80_RS10580 1947298..1947732 - 435 WP_000948842.1 PTS sugar transporter subunit IIA -
BLJ80_RS10585 1947750..1948628 - 879 WP_001705464.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
BLJ80_RS10590 1948618..1949397 - 780 WP_000406208.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
BLJ80_RS10595 1949408..1949881 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
BLJ80_RS10600 1949904..1951184 - 1281 WP_000681920.1 tagatose-bisphosphate aldolase subunit KbaZ -
BLJ80_RS10610 1951433..1952242 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
BLJ80_RS10615 1952297..1952761 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
BLJ80_RS10620 1952761..1953096 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
BLJ80_RS10625 1953245..1954816 - 1572 WP_001273790.1 galactarate dehydratase -
BLJ80_RS10630 1955191..1956489 + 1299 WP_001705462.1 galactarate/glucarate/glycerate transporter GarP -
BLJ80_RS10635 1956505..1957275 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T68196 WP_000347273.1 NZ_CP017844:c1952761-1952297 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T68196 NZ_CP017844:c1952761-1952297 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT68196 WP_001307405.1 NZ_CP017844:c1953096-1952761 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT68196 NZ_CP017844:c1953096-1952761 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References