Detailed information of TA system TA068187

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA-HipA
• Location: 1065580..1066928
• Replicon: chromosome
• Accession: NZ_CP017811
• Organism: Haemophilus influenzae strain NML-Hia-1

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: BG256_RS05265
• Protein ID: WP_071162982.1
• Coordinates: 1065580..1066611 (-)
• Length: 344 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: Q4QMQ1
• Locus tag: BG256_RS05270
• Protein ID: WP_011272158.1
• Coordinates: 1066608..1066928 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BG256_RS05255	1062102..1063847	+	1746	WP_071162980.1	ABC transporter ATP-binding protein/permease	-
BG256_RS05260	1063840..1065498	+	1659	WP_071162981.1	thiol reductant ABC exporter subunit CydC	-
BG256_RS05265	1065580..1066611	-	1032	WP_071162982.1	type II toxin-antitoxin system HipA family toxin	Toxin
BG256_RS05270	1066608..1066928	-	321	WP_011272158.1	type II toxin-antitoxin system HipA family toxin	Antitoxin
BG256_RS05275	1066916..1067224	-	309	WP_071162983.1	helix-turn-helix domain-containing protein	-
BG256_RS05280	1067429..1068430	-	1002	WP_071162984.1	class II fructose-bisphosphatase	-
BG256_RS05285	1068592..1068810	+	219	WP_005650820.1	cell division protein ZapB	-
BG256_RS05290	1068904..1069344	+	441	WP_005687918.1	FMN-binding protein MioC	-
BG256_RS05295	1069341..1069775	+	435	WP_005692418.1	D-tyrosyl-tRNA(Tyr) deacylase	-
BG256_RS05300	1070085..1070561	-	477	WP_042601042.1	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	-
BG256_RS05305	1070558..1071235	-	678	WP_014551114.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-
BG256_RS05310	1071235..1071513	-	279	WP_005665661.1	cell division protein FtsB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (56-290)

Antitoxin

• HipA, N-terminal subdomain 1 (9-101)

Sequences

Toxin

Protein

• Length: 344 a.a.
• Molecular weight: 39943.47 Da
• Isoelectric Point: 6.2879

>T68187 WP_071162982.1 NZ_CP017811:c1066611-1065580 [Haemophilus influenzae]
MNFCRILLKPLKKNEVHSGYSTKGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDDHFDSVDQQ
GNYILKPSPEEYPFLAENEHATMRIMKELEFDVPENGLVSFAGEQNQKEFAFVIKRFDRDEQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQQEIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
ETFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLFLLNVLNEPEL

Nucleotide

• Length: 1032 bp

>T68187 NZ_CP017811:c1066611-1065580 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTGAAGAAAAATGAAGTTCATTCTGGTTACAGCACAAAAGGTTTACACTA
TCTTACAGGCAATAAACATTTTAATCCTGAATTGCCCTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGGATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCAAAGATGATCACTTTGACAGCGTAGATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACATGCCACCATGCGCATTATGAA
AGAATTAGAATTTGACGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCAGAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAGCAAAAACCAATGCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TATGGAAAAATAGGTGCTGATAATGAGCAATATGTGAGTTATGAACAAATTGCTAAGTTTATTTTGCAGCACACTGAAAA
TCATTTAGCTCAGCAACAAGAGATTTTCCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGACTTTGTGTCGGTGTCGCCCTACCCT
GAAACATTTAATTCAACACTACTTGCCTTGCCATTGTTAGCGAGAGAAGAGGGTAATGCCACACTCGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTACACAAGAAAAGGAAAAGGTGGAGCAGATTTATTCACAATCCTTTATGCCGCAACCGCAT
ATTGATTGTGTACTGAAAACTTATCGCAAGCGTTTATTTTTGCTTAACGTATTAAATGAACCTGAACTATAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12437.12 Da
• Isoelectric Point: 5.9670

>AT68187 WP_011272158.1 NZ_CP017811:c1066928-1066608 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFAYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
ESDMFRFLLNNGENMLGAVQIQEEKQ

Nucleotide

• Length: 321 bp

>AT68187 NZ_CP017811:c1066928-1066608 [Haemophilus influenzae]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGCGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTGCTTACAATCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGTCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCCCTCGTCCCCGAAGGCTGGCTAAAACACAAATATGCACTTCATCAACGAATTGAT
GAAAGCGATATGTTTCGCTTTTTACTTAATAACGGGGAAAATATGTTAGGCGCAGTGCAAATTCAGGAGGAAAAACAATG
A

Structures

Antitoxin

• AlphaFold DB: Q4QMQ1