Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 101251..101908 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP017778 | ||
| Organism | Klebsiella pneumoniae strain KP36M | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | BK002_RS26360 | Protein ID | WP_000270043.1 |
| Coordinates | 101251..101601 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | BK002_RS26365 | Protein ID | WP_000124640.1 |
| Coordinates | 101606..101908 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BK002_RS26325 | 97725..98222 | - | 498 | WP_000062185.1 | hypothetical protein | - |
| BK002_RS26330 | 98225..98713 | - | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| BK002_RS26335 | 98810..99145 | + | 336 | WP_000683476.1 | hypothetical protein | - |
| BK002_RS26340 | 99160..99630 | - | 471 | WP_001281821.1 | hypothetical protein | - |
| BK002_RS26345 | 99623..99994 | - | 372 | WP_000516916.1 | hypothetical protein | - |
| BK002_RS26350 | 100005..100199 | - | 195 | WP_000343597.1 | hypothetical protein | - |
| BK002_RS26355 | 100540..101088 | - | 549 | WP_001061574.1 | transcriptional regulator | - |
| BK002_RS26360 | 101251..101601 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| BK002_RS26365 | 101606..101908 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| BK002_RS26370 | 101935..102228 | - | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| BK002_RS26375 | 102316..102588 | - | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| BK002_RS26380 | 102646..103173 | - | 528 | WP_001236377.1 | thermonuclease family protein | - |
| BK002_RS26385 | 103404..104261 | - | 858 | WP_001167032.1 | hypothetical protein | - |
| BK002_RS26390 | 104248..104478 | - | 231 | WP_000972663.1 | hypothetical protein | - |
| BK002_RS26395 | 104478..104996 | - | 519 | WP_000210756.1 | nitrite reductase | - |
| BK002_RS26400 | 104993..105439 | - | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| BK002_RS26405 | 105439..105798 | - | 360 | WP_000422768.1 | hypothetical protein | - |
| BK002_RS26410 | 105855..106283 | - | 429 | WP_000591074.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | sul1 / qnrB2 / sul2 / erm(42) | - | 1..225961 | 225961 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T68149 WP_000270043.1 NZ_CP017778:101251-101601 [Klebsiella pneumoniae]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T68149 NZ_CP017778:101251-101601 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT68149 WP_000124640.1 NZ_CP017778:101606-101908 [Klebsiella pneumoniae]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT68149 NZ_CP017778:101606-101908 [Klebsiella pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|