Detailed information of TA system TA068080

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 242506..243157
• Replicon: plasmid pCFSAN017963_01
• Accession: NZ_CP017721
• Organism: Salmonella enterica subsp. enterica serovar Minnesota strain CFSAN017963

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A5V7PA07
• Locus tag: GX95_RS25415
• Protein ID: WP_071624850.1
• Coordinates: 242506..242856 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A616MHC7
• Locus tag: GX95_RS25420
• Protein ID: WP_071624849.1
• Coordinates: 242858..243157 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GX95_RS25390	237808..238320	+	513	WP_088137290.1	CaiF/GrlA family transcriptional regulator	-
GX95_RS25395	238503..238931	+	429	WP_157719440.1	helix-turn-helix transcriptional regulator	-
GX95_RS25400	238942..239445	+	504	WP_088137291.1	CaiF/GrlA family transcriptional regulator	-
GX95_RS25410	240764..242098	+	1335	WP_088137303.1	reverse transcriptase/maturase family protein	-
GX95_RS25415	242506..242856	+	351	WP_071624850.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GX95_RS25420	242858..243157	+	300	WP_071624849.1	XRE family transcriptional regulator	Antitoxin
GX95_RS25425	243160..243908	+	749	Protein_240	IS66 family transposase	-
GX95_RS25430	243931..245397	-	1467	WP_088137304.1	C69 family dipeptidase	-
GX95_RS25440	245847..246626	+	780	WP_080092426.1	tyrosine-type recombinase/integrase	-
GX95_RS25445	246950..247423	+	474	WP_088137305.1	CaiF/GrlA family transcriptional regulator	-
GX95_RS25450	247420..248049	+	630	WP_071624716.1	LuxR C-terminal-related transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..280421	280421

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 15014.38 Da
• Isoelectric Point: 12.8644

>T68080 WP_071624850.1 NZ_CP017721:242506-242856 [Salmonella enterica subsp. enterica serovar Minnesota]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 351 bp

>T68080 NZ_CP017721:242506-242856 [Salmonella enterica subsp. enterica serovar Minnesota]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 12835.43 Da
• Isoelectric Point: 12.7956

>AT68080 WP_071624849.1 NZ_CP017721:242858-243157 [Salmonella enterica subsp. enterica serovar Minnesota]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 300 bp

>AT68080 NZ_CP017721:242858-243157 [Salmonella enterica subsp. enterica serovar Minnesota]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: A0A5V7PA07

Antitoxin

• AlphaFold DB: A0A616MHC7