Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2408035..2408552 Replicon chromosome
Accession NZ_CP017680
Organism Staphylococcus aureus strain CFSAN007851

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag AB454_RS12480 Protein ID WP_000113262.1
Coordinates 2408035..2408301 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag AB454_RS12485 Protein ID WP_000584499.1
Coordinates 2408301..2408552 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB454_RS12455 2403463..2403990 - 528 WP_000973468.1 GNAT family N-acetyltransferase -
AB454_RS12460 2404234..2405058 - 825 WP_000572040.1 formate/nitrite transporter family protein -
AB454_RS12465 2405275..2405457 - 183 WP_000230294.1 hypothetical protein -
AB454_RS12470 2405541..2406008 - 468 WP_000153344.1 SRPBCC domain-containing protein -
AB454_RS12475 2406194..2407741 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
AB454_RS12480 2408035..2408301 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
AB454_RS12485 2408301..2408552 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AB454_RS12490 2408717..2408818 - 102 Protein_2293 hypothetical protein -
AB454_RS12495 2408825..2409424 - 600 WP_000162810.1 DsbA family protein -
AB454_RS12500 2409443..2409805 - 363 WP_000819843.1 DUF4467 domain-containing protein -
AB454_RS12505 2410060..2411310 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
AB454_RS12510 2411407..2412138 - 732 WP_000615458.1 amino acid ABC transporter ATP-binding protein -
AB454_RS12515 2412135..2412854 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T68011 WP_000113262.1 NZ_CP017680:c2408301-2408035 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T68011 NZ_CP017680:c2408301-2408035 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAAATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT68011 WP_000584499.1 NZ_CP017680:c2408552-2408301 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT68011 NZ_CP017680:c2408552-2408301 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References