Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1983086..1983500 Replicon chromosome
Accession NZ_CP017677
Organism Staphylococcus aureus strain CFSAN007894

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AB466_RS10085 Protein ID WP_001065046.1
Coordinates 1983249..1983500 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AB466_RS14280 Protein ID WP_000028424.1
Coordinates 1983086..1983259 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB466_RS10025 1978650..1978994 - 345 WP_000817289.1 HNH endonuclease -
AB466_RS10030 1979010..1979462 - 453 WP_000406191.1 nucleoside triphosphate pyrophosphohydrolase family protein -
AB466_RS10035 1979577..1980047 - 471 WP_000282758.1 hypothetical protein -
AB466_RS10045 1980070..1980270 - 201 WP_000265041.1 DUF1514 family protein -
AB466_RS10050 1980270..1980920 - 651 WP_001005262.1 hypothetical protein -
AB466_RS10055 1981079..1981228 - 150 WP_000595305.1 transcriptional activator RinB -
AB466_RS10060 1981225..1981611 - 387 WP_000592201.1 hypothetical protein -
AB466_RS10065 1981608..1981814 - 207 WP_000195803.1 DUF1381 domain-containing protein -
AB466_RS10070 1981811..1982056 - 246 WP_001282074.1 hypothetical protein -
AB466_RS10075 1982093..1982626 - 534 WP_001061838.1 dUTP diphosphatase -
AB466_RS14275 1982641..1982802 - 162 WP_000889682.1 hypothetical protein -
AB466_RS10080 1982803..1983060 - 258 WP_031866878.1 hypothetical protein -
AB466_RS14280 1983086..1983259 - 174 WP_000028424.1 hypothetical protein Antitoxin
AB466_RS10085 1983249..1983500 - 252 WP_001065046.1 DUF1024 family protein Toxin
AB466_RS10090 1983515..1983757 - 243 WP_000131381.1 phi PVL orf 51-like protein -
AB466_RS10095 1983761..1984129 - 369 WP_000101270.1 hypothetical protein -
AB466_RS10100 1984142..1984597 - 456 WP_000401965.1 RusA family crossover junction endodeoxyribonuclease -
AB466_RS10105 1984606..1984824 - 219 WP_000338527.1 hypothetical protein -
AB466_RS10110 1984831..1985691 - 861 WP_099112241.1 DnaD domain-containing protein -
AB466_RS10115 1985721..1986191 - 471 WP_000934762.1 single-stranded DNA-binding protein -
AB466_RS10120 1986192..1986809 - 618 WP_072353921.1 MBL fold metallo-hydrolase -
AB466_RS10125 1986890..1987810 - 921 WP_000138475.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / sak / hlb / groEL 1954736..2005726 50990


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9377.26 Da        Isoelectric Point: 3.7128

>T67981 WP_001065046.1 NZ_CP017677:c1983500-1983249 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T67981 NZ_CP017677:c1983500-1983249 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAATCAATTATCAGTGCTAGTGCCTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGGTTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT67981 WP_000028424.1 NZ_CP017677:c1983259-1983086 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT67981 NZ_CP017677:c1983259-1983086 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGATGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References